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glucokinase regulator

Summary

Gene Symbol

Gckr

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25658

PubChem

25658

Alliance of Genome Resources

RGD:2671

Annotation

Keyword

3D-structure
Carbohydrate metabolism
Cytoplasm
Direct protein sequencing
Kinase
Mitochondrion
Nucleus
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q07071
A6HA55

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
intracellular glucose homeostasis	IBA ISO
glucose metabolic process	TAS	11756407
negative regulation of hexokinase activity	IDA	14627435
response to fructose	IDA ISO	14627435
negative regulation of glucokinase activity	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

urate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

carbohydrate derivative metabolic process

organic cyclic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

intracellular glucose homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of hexokinase activity [inference]

regulation of glucokinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of glucokinase activity [inference]

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of glucokinase activity [inference]

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of hexokinase activity [inference]

regulation of glucokinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

regulation of hexokinase activity [inference]

regulation of glucokinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of hexokinase activity [inference]

positive regulation of glucokinase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of hexokinase activity

negative regulation of glucokinase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA ISO	10601273
cytoplasm	IDA	10518020 10601273
nucleoplasm	IBA IDA ISO	10518020
cytosol	ISO
mitochondrion	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
fructose-6-phosphate binding	IBA ISO ISS
glucose sensor activity	IBA IDA ISO	14627435 19807849
carbohydrate binding	IDA IMP	11756407 14627435
enzyme inhibitor activity	IDA	11756407 14627435
protein domain specific binding	IPI	16186382

GO Hierarchy

kinase binding

protein domain specific binding

carbohydrate binding

ion binding [inference]

anion binding [inference]

fructose-6-phosphate binding

carbohydrate derivative binding [inference]

fructose-6-phosphate binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

kinase inhibitor activity

kinase regulator activity [inference]

kinase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

kinase inhibitor activity

small molecule sensor activity [inference]

glucose sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

glucokinase regulatory protein

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
amino sugar catabolic process
carbohydrate derivative binding
carbohydrate derivative metabolic process
carbon-oxygen lyase activity
enzyme binding
ether hydrolase activity
fructose-6-phosphate binding
glucose homeostasis
response to fructose

Displaying **all 2** entries
InterPro
N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein
SIS domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2646		HGNC:4196	HUMAN62021
Mus musculus	231103	10090_1:001617	MGI:1096345	MOUSE46463
Pan troglodytes	459107			PANTR27298
Canis lupus familiaris	475705			CANLF04993
Macaca mulatta	701431			MACMU08541
Monodelphis domestica	100031179			MONDO09435
Equus caballus	100071177			HORSE09701
Oryctolagus cuniculus	100350724			RABIT08764
Callithrix jacchus	100388988			CALJA10263
Pongo abelii	100439794			PONAB23716

GlyTouCan

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LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements