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insulin-like growth factor binding protein 1

Summary

Gene Symbol

Igfbp1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25685

PubChem

25685

Alliance of Genome Resources

RGD:2872

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P21743

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
glucose metabolic process	TAS	15350195
insulin receptor signaling pathway	IEP	11784721
response to organic cyclic compound
positive regulation of cell growth	IEP	1705004
response to insulin	ISO

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

tissue regeneration

growth [inference]

developmental growth [inference]

tissue regeneration

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	16166214
extracellular space	IBA
Golgi apparatus	ISO
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
insulin-like growth factor binding	ISO
insulin-like growth factor binding	TAS	15070850
insulin-like growth factor I binding	ISO
insulin-like growth factor I binding	IBA
insulin-like growth factor II binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

insulin-like growth factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

insulin like growth factor binding protein 1

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
growth factor binding
insulin-like growth factor I binding
insulin-like growth factor II binding
insulin-like growth factor binding
regulation of insulin-like growth factor receptor signaling pathway

Displaying **all 7** entries
InterPro
Growth factor receptor cysteine-rich domain superfamily
Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
Insulin-like growth factor-binding protein 1
Insulin-like growth factor-binding protein family 1-6, chordata
Insulin-like growth factor-binding protein, IGFBP
Thyroglobulin type-1 superfamily
Thyroglobulin type-1

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:16166214

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3484		HUMAN88879
Mus musculus	16006		MOUSE07064
Xenopus tropicalis	25685	Xenbase:XB-GENE-485497
Bos taurus	282259		BOVIN28214
Danio rerio	317638		DANRE18776
Sus scrofa	397270		PIGXX12942
Ovis aries	443132		SHEEP15588
Pan troglodytes	463395		PANTR40213
Canis lupus familiaris	480812		CANLF04394
Macaca mulatta	696994		MACMU33269

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements