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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glial cell derived neurotrophic factor
Summary
- Gene Symbol
-
- GDNF
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Growth factor
- Hirschsprung disease
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P39905 |
|
| A0A0S2Z3T2 |
|
| A0A0S2Z3V2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| mRNA stabilization | ||
| branching involved in ureteric bud morphogenesis | ||
| glial cell-derived neurotrophic factor receptor signaling pathway | ||
| embryonic organ development |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi apparatus | ||
| extracellular region | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| signaling receptor binding | ||
| glial cell-derived neurotrophic factor receptor binding | ||
| growth factor activity | ||
| protein homodimerization activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- glial cell derived neurotrophic factor
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Cystine-knot cytokine |
| Glial cell line-derived neurotrophic factor family |
| Transforming growth factor-beta, C-terminal |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:0060161 | Kennedy's disease | |
| DOID:0080855 | Parkinsonism | |
| DOID:10487 | Hirschsprung's disease | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10933 | obsessive-compulsive disorder | |
| DOID:11446 | sciatic neuropathy | |
| DOID:12689 | acoustic neuroma | |
| DOID:12700 | hyperprolactinemia | |
| DOID:12842 | Guillain-Barre syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 14573 | MGI:107430 | MOUSE15283 | ||
| 25453 | RGD:2677 | RATNO24374 | ||
| 79379 | ZFIN:ZDB-GENE-010226-1 | DANRE00013 | ||
| 386587 | BOVIN16034 | |||
| 471566 | 9598_0:0018b4 | PANTR35683 | ||
| 706345 | MACMU39656 | |||
| 779087 | Xenbase:XB-GENE-865016 | |||
| 100067053 | HORSE20244 | |||
| 100081598 | ORNAN18648 | |||
| 100229958 | TAEGU31303 |
