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gephyrin

Summary

Gene Symbol

Gphn

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

268566

PubChem

268566

Alliance of Genome Resources

MGI:109602

Annotation

Keyword

ATP-binding
Cell membrane
Cell projection
Cytoskeleton
Magnesium
Metal-binding
Molybdenum
Molybdenum cofactor biosynthesis
Multifunctional enzyme
Palmitate
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Transferase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0JNY3
Q8BUV3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
Mo-molybdopterin cofactor biosynthetic process	ISO
Mo-molybdopterin cofactor biosynthetic process	IMP	9812897
Mo-molybdopterin cofactor biosynthetic process	IBA
establishment of synaptic specificity at neuromuscular junction	IMP	10531433
establishment of synaptic specificity at neuromuscular junction	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

prosthetic group metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

establishment of synaptic specificity at neuromuscular junction

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of localization [inference]

establishment of protein localization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
intracellular anatomical structure	IDA	17145751
cytoplasm	ISO
cytoplasm	IBA
cytosol	IDA	18411266 25025157
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane

postsynaptic membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization

postsynaptic density

cell body [inference]

neuronal cell body

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

postsynapse

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
protein binding	IPI	17347650 21829170 27609886 29107521
ATP binding	IEA
cytoskeletal protein binding	TAS	10531433
nitrate reductase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

nitrate reductase activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

molybdopterin adenylyltransferase activity

molybdopterin molybdotransferase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

molybdopterin cofactor binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

gephyrin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
P: Inorganic ion transport and metabolism

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
ATP binding
Mo-molybdopterin cofactor biosynthetic process
establishment of synaptic specificity at neuromuscular junction
gamma-aminobutyric acid receptor clustering
glycine receptor clustering
metal ion binding
molybdopterin adenylyltransferase activity
molybdopterin cofactor biosynthetic process
molybdopterin molybdotransferase activity
organic cyclic compound metabolic process

Displaying **all 5** entries
InterPro
MoaB/Mog domain
MoaB/Mog-like domain superfamily
MoeA, N-terminal and linker domain
Molybdenum cofactor biosynthesis, conserved site
Molybdopterin biosynthesis protein MoeA-like

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10243	Xenbase:XB-GENE-989642	HUMAN19879
Rattus norvegicus	64845		RATNO36560
Xenopus tropicalis	268566	Xenbase:XB-GENE-989642
Pan troglodytes	452976		PANTR08992
Canis lupus familiaris	490739		CANLF18008
Bos taurus	535194		BOVIN01578
Danio rerio	555470		DANRE13315
Macaca mulatta	709677		MACMU42517
Danio rerio	100007749		DANRE19809
Monodelphis domestica	100022949		MONDO05385

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements