GlyCosmos Portal

Annotation

Keyword

ATP-binding
Cell membrane
Cell projection
Cytoskeleton
Magnesium
Metal-binding
Molybdenum
Molybdenum cofactor biosynthesis
Multifunctional enzyme
Palmitate
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Transferase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0JNY3
Q8BUV3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
response to metal ion	ISO
molybdopterin cofactor biosynthetic process	IMP ISO ISS	12565882 18411266
establishment of protein localization	ISO
Mo-molybdopterin cofactor biosynthetic process	IBA IMP ISO	9812897
glycine receptor clustering	IBA IMP	9812897

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

prosthetic group metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

maintenance of postsynaptic specialization structure

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure

synapse organization [inference]

establishment of synaptic specificity at neuromuscular junction

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of localization [inference]

establishment of protein localization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
inhibitory synapse	IDA ISO	21119615 24613359 9812897
postsynaptic membrane	IBA ISO ISS
postsynaptic specialization, intracellular component	IDA ISO	19955355
postsynaptic density	IDA	27609886
postsynapse	IDA ISO	24554721

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization

postsynaptic density

cell body [inference]

neuronal cell body

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

postsynapse

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17347650 21829170 27609886 29107521
signaling receptor binding	ISO
nitrate reductase activity	ISO
metal ion binding	IEA
identical protein binding	ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

nitrate reductase activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

molybdopterin adenylyltransferase activity

molybdopterin molybdotransferase activity

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

molybdopterin cofactor binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

gephyrin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
P: Inorganic ion transport and metabolism

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
ATP binding
Mo-molybdopterin cofactor biosynthetic process
establishment of synaptic specificity at neuromuscular junction
gamma-aminobutyric acid receptor clustering
glycine receptor clustering
metal ion binding
molybdopterin adenylyltransferase activity
molybdopterin cofactor biosynthetic process
molybdopterin molybdotransferase activity
organic cyclic compound metabolic process

Displaying **all 5** entries
InterPro
MoaB/Mog domain
MoaB/Mog-like domain superfamily
MoeA, N-terminal and linker domain
Molybdenum cofactor biosynthesis, conserved site
Molybdopterin biosynthesis protein MoeA-like

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111166	molybdenum cofactor deficiency type C	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **107** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10243		HGNC:15465	HUMAN19879
Drosophila melanogaster	30973		FB:FBgn0000316
Rattus norvegicus	64845	10116_1:0024c5	RGD:69194	RATNO36560
Pan troglodytes	452976			PANTR08992
Canis lupus familiaris	490739			CANLF18008
Bos taurus	535194			BOVIN01578
Danio rerio	555470		ZFIN:ZDB-GENE-110127-3	DANRE13315
Macaca mulatta	709677			MACMU42517
Danio rerio	100007749		ZFIN:ZDB-GENE-070705-4	DANRE19809
Monodelphis domestica	100022949			MONDO05385

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements