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paraoxonase 3

Summary

Gene Symbol

Pon3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

269823

PubChem

269823

Alliance of Genome Resources

MGI:106686

Annotation

Keyword

Calcium
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q62087

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IBA
establishment of localization in cell	IDA IMP IPI	32079677
carboxylic acid catabolic process	IEA ISO
renal sodium ion transport	IDA IMP IPI	32079677
negative regulation of superoxide anion generation	IDA	22441669

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

aromatic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

xenobiotic catabolic process [inference]

phenylacetate catabolic process

heterocycle catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

organic cyclic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

lactone catabolic process

secondary metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process [inference]

coumarin catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

cellular aromatic compound metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process [inference]

coumarin catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

aromatic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

benzene-containing compound metabolic process [inference]

phenylacetate catabolic process

xenobiotic metabolic process [inference]

xenobiotic catabolic process [inference]

phenylacetate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

aromatic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

xenobiotic catabolic process [inference]

phenylacetate catabolic process

heterocycle catabolic process [inference]

heterocycle metabolic process [inference]

coumarin metabolic process [inference]

coumarin catabolic process

heterocycle catabolic process [inference]

lactone metabolic process [inference]

lactone catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

organic cyclic compound metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process [inference]

coumarin catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

benzene-containing compound metabolic process [inference]

phenylacetate catabolic process

lactone metabolic process [inference]

lactone catabolic process

organic cyclic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

lactone catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

organic cyclic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

lactone catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

cellular aromatic compound metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process [inference]

coumarin catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

aromatic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

benzene-containing compound metabolic process [inference]

phenylacetate catabolic process

xenobiotic metabolic process [inference]

xenobiotic catabolic process [inference]

phenylacetate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

aromatic compound catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

xenobiotic catabolic process [inference]

phenylacetate catabolic process

heterocycle catabolic process [inference]

heterocycle metabolic process [inference]

coumarin metabolic process [inference]

coumarin catabolic process

heterocycle catabolic process [inference]

lactone metabolic process [inference]

lactone catabolic process

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal sodium ion transport

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of response to stimulus [inference]

regulation of response to drug [inference]

regulation of cellular response to drug

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular response to drug

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
3,4-dihydrocoumarin hydrolase activity
metal ion binding	IEA
arylesterase activity	IBA IEA ISO
dihydrocoumarin hydrolase activity	ISO
acyl-L-homoserine-lactone lactonohydrolase activity	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

aryldialkylphosphatase activity

carboxylic ester hydrolase activity [inference]

lactonohydrolase activity [inference]

acyl-L-homoserine-lactone lactonohydrolase activity

dihydrocoumarin hydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

serum paraoxonase/lactonase 3

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
acyl-L-homoserine-lactone lactonohydrolase activity
arylesterase activity
hydrolase activity
metal ion binding
response to toxic substance

Displaying **all 2** entries
InterPro
Arylesterase
Six-bladed beta-propeller, TolB-like

Rhea

RHEA:22576

H₂O + an N-acyl-L-homoserine lactone

H⁺ + an N-acyl-L-homoserine

Enzyme

3.1.1.81

PMID

RHEA:18053

H₂O + paraoxon

diethylphosphate + H⁺ + 4-nitrophenol

Enzyme

3.1.8.1

PMID

RHEA:17309

a phenyl acetate + H₂O

H⁺ + acetate + a phenol

Enzyme

3.1.1.2

PMID

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:10608	celiac disease	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources
DOID:8577	ulcerative colitis	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP004092
Gene Name: paraoxonase 3

Ortholog

Displaying entries **11 - 20** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	4363028		WB:WBGene00044697
Caenorhabditis elegans	6418581		WB:WBGene00077701
Equus caballus	100051959			HORSE32860
Ovis aries	100337686			SHEEP15304
Pongo abelii	100436262			PONAB32953
Ailuropoda melanoleuca	100467660			AILME13080
Nomascus leucogenys	100603110			NOMLE03139
Loxodonta africana	100675274			LOXAF17691
Cavia porcellus	100721546	10141_0:00399d		CAVPO06115
Cricetulus griseus	100762826	10029_0:000616		CRIGR15698

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements