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MIRAGE

Ca2+-dependent secretion activator

Summary

Gene Symbol

Cadps

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

27062

PubChem

27062

Alliance of Genome Resources

MGI:1350922

Annotation

Keyword

Alternative splicing
Calcium
Cytoplasmic vesicle
Exocytosis
Lipid-binding
Membrane
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q80TJ1	Calcium-dependent activator protein for secretion 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
exocytosis	IMP	15820695
protein transport	IEA
vesicle organization	IMP	15820695
synaptic vesicle priming	IDA	18022372
synaptic vesicle priming	IMP	18022372

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

synaptic vesicle priming

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

synaptic vesicle priming

exocytic process [inference]

synaptic vesicle priming

export from cell [inference]

secretion by cell [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

catecholamine secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

secretion [inference]

secretion by cell [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

catecholamine secretion

organic substance transport [inference]

protein transport

monoamine transport [inference]

catecholamine transport [inference]

catecholamine secretion

organic hydroxy compound transport [inference]

catecholamine transport [inference]

catecholamine secretion

nitrogen compound transport [inference]

protein transport

monoamine transport [inference]

catecholamine transport [inference]

catecholamine secretion

export from cell [inference]

secretion by cell [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

catecholamine secretion

establishment of protein localization [inference]

protein transport

establishment of localization in cell

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
dense core granule	ISO
cytoplasmic vesicle	IDA	15820695
extrinsic component of neuronal dense core vesicle membrane	ISO
presynapse	ISO
presynapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

dense core granule membrane [inference]

neuronal dense core vesicle membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

dense core granule membrane [inference]

neuronal dense core vesicle membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of dense core granule membrane [inference]

extrinsic component of neuronal dense core vesicle membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

presynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
calcium ion binding	ISO
protein binding	IPI	12659812
phosphatidylinositol-4,5-bisphosphate binding	ISO
lipid binding	IEA
protein kinase binding	IPI	21307259

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Calcium-dependent secretion activator

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
dense core granule exocytosis
positive regulation of exocytosis
synaptic vesicle exocytosis

Displaying **all 2** entries
InterPro
Calcium-dependent secretion activator
MUN domain

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8618	Xenbase:XB-GENE-5755926	HUMAN70809
Rattus norvegicus	26989		RATNO09735
Xenopus tropicalis	27062	Xenbase:XB-GENE-5755926
Drosophila melanogaster	320405	FB:FBgn0053653
Pan troglodytes	460485		PANTR31468
Canis lupus familiaris	484705		CANLF07375
Bos taurus	534328		BOVIN17567
Macaca mulatta	703270		MACMU28256
Ornithorhynchus anatinus	100078196		ORNAN28235
Taeniopygia guttata	100228459		TAEGU03793

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Last updated: December 8, 2025