GlyCosmos Portal

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Glycosidase
Lipid metabolism
Lysosome
Pharmaceutical
RNA editing
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P06280	Alpha-D-galactosidase A Alpha-D-galactoside galactohydrolase Galactosylgalactosylglucosylceramidase GLA Melibiase
Q53Y83

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
glycosphingolipid catabolic process	IDA IMP TAS	10838196 2160973 8804427
negative regulation of nitric oxide biosynthetic process	ISS
glycoside catabolic process	IBA
negative regulation of nitric-oxide synthase activity	ISS
oligosaccharide metabolic process	IBA IDA	39940

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

glycoside catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glycosylceramide catabolic process

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

glycosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nitric oxide metabolic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of nitric oxide biosynthetic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

negative regulation of nitric-oxide synthase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular region	IDA IMP TAS	1332979 3029062
cytoplasm	IBA IMP	1332979
Golgi apparatus	IMP	1332979
lysosomal lumen	TAS
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
catalytic activity	IDA	39940
hydrolase activity	TAS	7911050
protein homodimerization activity	IDA	6256390
galactoside binding	IEA
signaling receptor binding	IDA	1332979

GO Hierarchy

molecular function

catalytic activity

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

galactosidase activity [inference]

alpha-galactosidase activity

binding [inference]

protein binding

signaling receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate derivative binding [inference]

galactoside binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000102393

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01189

Name

alpha-galactosidase [EC:3.2.1.22]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05961	3.2.1.22	G00059MO	G84224TW

Rhea

RHEA:21112

H₂O + a globoside Gb3Cer (d18:1(4E))

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + D-galactose

Enzyme

3.2.1.22

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **177** in total

1

2

3

4

5

…

Next ›

Last »
DO ID	Disease Name	Source
DOID:399	tuberculosis	DisGeNET
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050452	mevalonic aciduria	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET DisGeNET
DOID:0050778	Meckel syndrome	DisGeNET
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:0050820	atrioventricular block	DisGeNET
DOID:0060224	atrial fibrillation	DisGeNET
DOID:0060357	chylomicron retention disease	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 80 in total

1

2

3

4

5

…

Next ›

Last »
HPO ID	HPO Term
HP:0000083	Renal insufficiency
HP:0000091	Abnormal renal tubule morphology
HP:0000093	Proteinuria
HP:0000100	Nephrotic syndrome
HP:0000112	Nephropathy
HP:0000179	Thick lower lip vermilion
HP:0000280	Coarse facial features
HP:0000365	Hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000518	Cataract

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:324	Fabry disease
OMIM:301500	Fabry disease

PubChem Disease

GHR Health Conditions

Fabry disease

MedGen Diseases

Angiokeratoma corporis diffusum

OMIM Phenotypes

FABRY DISEASE

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000589
Gene Name: galactosidase, alpha

Ortholog

Displaying entries **1 - 10** of 79 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179660	WB:WBGene00011095
Drosophila melanogaster	36829	FB:FBgn0034117
Petromyzon marinus	116943621		PETMA07618
Latimeria chalumnae	102347864		LATCH16391
Danio rerio	450083	ZFIN:ZDB-GENE-041010-207	DANRE07182
Salmo salar	100380380		SALSA125615
Salmo trutta	115169827		SALTR43960
Gadus morhua	115552107		GADMO00720
Oryzias latipes	101169044		ORYLA00952
Oreochromis niloticus	100711467		ORENI47872

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements