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sphingomyelin phosphodiesterase acid like 3B

Summary

Gene Symbol

SMPDL3B

Aliases

ASML3B

Organism

Homo sapiens (human)

External Links

NCBI Gene

27293

HGNC

21416

KEGG Gene ID

hsa:27293

PubChem

27293

Alliance of Genome Resources

HGNC:21416

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
GPI-anchor
Glycosidase
Hydrolase
Inflammatory response
Innate immunity
Lipid degradation
Metal-binding
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q92485
B4DW34
B4DEC6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sphingomyelin catabolic process	IEA
inflammatory response	IEA
negative regulation of toll-like receptor signaling pathway	ISS
innate immune response	IEA
membrane lipid catabolic process	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular space	HDA	16502470
plasma membrane	ISS
extracellular exosome	HDA	19056867 23533145
side of membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
sphingomyelin phosphodiesterase activity	IEA
protein binding	IPI	31217420
phosphoric diester hydrolase activity	ISS
phosphoric diester hydrolase activity	IMP	26095358
phosphoric diester hydrolase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

sphingomyelin phosphodiesterase activity

hydrolase activity, acting on glycosyl bonds

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Acid sphingomyelinase-like phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
endopolyphosphatase activity
exopolyphosphatase activity
hydrolase activity
polyphosphate catabolic process

Displaying **all 3** entries
InterPro
Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain
Calcineurin-like phosphoesterase domain, ApaH type
Metallo-dependent phosphatase-like

KEGG BRITE Database

Orthology

K01128

Name

sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-]

References

25288789

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006344
Gene Name: sphingomyelin phosphodiesterase, acid-like 3B

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	6609	SGD:S000002860
Saccharomyces cerevisiae S288C	10924	SGD:S000002860
Saccharomyces cerevisiae S288C	20597	SGD:S000002860
Xenopus tropicalis	27293	Xenbase:XB-GENE-993034
Saccharomyces cerevisiae S288C	57319	SGD:S000002860
Mus musculus	100340	Xenbase:XB-GENE-993034	MOUSE40335
Saccharomyces cerevisiae S288C	294422	SGD:S000002860
Rattus norvegicus	362619		RATNO34593
Pan troglodytes	456681		PANTR20408
Bos taurus	518699		BOVIN25073

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements