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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glycine decarboxylase
Summary
- Gene Symbol
-
- GLDC
- Aliases
-
- GCSP
- NKH
- glycine cleavage system protein P
- glycine dehydrogenase
- nonketotic hyperglycinemia
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Disease variant
- Mitochondrion
- Oxidoreductase
- Pyridoxal phosphate
- Reference proteome
- Transit peptide
- Proteins
| UniProt | Protein Name |
|---|---|
| P23378 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine decarboxylation via glycine cleavage system | ||
| glycine catabolic process | ||
| response to methylamine | ||
| cellular response to leukemia inhibitory factor | ||
| response to lipoic acid |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine cleavage complex | ||
| plasma membrane | ||
| mitochondrial matrix |
|
|
| mitochondrion | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine binding | ||
| glycine dehydrogenase (decarboxylating) activity |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:308 | early myoclonic encephalopathy | |
| DOID:3347 | osteosarcoma | |
| DOID:3376 | bone osteosarcoma | |
| DOID:3490 | Noonan syndrome | |
| DOID:3535 | Unverricht-Lundborg syndrome | |
| DOID:3571 | liver cancer | |
| DOID:3620 | central nervous system cancer | |
| DOID:3683 | lung benign neoplasm | |
| DOID:3904 | bronchus carcinoma | |
| DOID:3905 | lung carcinoma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000711 | Restlessness |
| HP:0000718 | Aggressive behavior |
| HP:0000737 | Irritability |
| HP:0000752 | Hyperactivity |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001254 | Lethargy |
| HP:0001265 | Hyporeflexia |
| Disease ID | Disease Name |
|---|---|
| OMIM:605899 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100943493 | OTOGA17684 | ||
| 101068418 | TAKRU29209 | ||
| 102013644 | CHILA09589 | ||
| 105716636 | AOTNA19401 | ||
| 101027438 | SAIBB13744 | ||
| 101598152 | JACJA04369 | ||
| 118313585 | SCOMX33288 | ||
| 102422643 | MYOLU15372 | ||
| 117032416 | RHIFE21536 | ||
| 100231195 | TAEGU31671 |
