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LIF interleukin 6 family cytokine

Summary

Gene Symbol

LIF

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280840
PubChem: 280840

Annotation

Keyword

Cytokine
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q27956	bLIF

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
immune response	IEA	22301074
positive regulation of cell population proliferation	IEA	30032202
regulation of cell communication
regulation of signaling
regulation of cell differentiation	IEA	30032202

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of developmental process [inference]

regulation of cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

regulation of cell communication

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074 30032202
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA	22301074 30032202
leukemia inhibitory factor receptor binding	IEA	22301074 30032202
growth factor activity	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

leukemia inhibitory factor receptor binding

receptor ligand activity [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Leukemia inhibitory factor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
Gene Ontology
cytokine activity
growth factor activity
immune response
leukemia inhibitory factor receptor binding
leukemia inhibitory factor signaling pathway
positive regulation of cell population proliferation
regulation of cell differentiation
signaling receptor binding

Displaying **all 3** entries
InterPro
Four-helical cytokine-like, core
Leukemia inhibitory factor /oncostatin
Leukemia inhibitory factor

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	3976	HUMAN59884
Mus musculus	16878	MOUSE06347
Rattus norvegicus	60584	RATNO08010
Sus scrofa	399503	PIGXX07157
Canis lupus familiaris	403449	CANLF10470
Macaca mulatta	715456	MACMU00903
Pan troglodytes	736309	PANTR26310
Monodelphis domestica	100018708	MONDO19961
Oryctolagus cuniculus	100358914	RABIT14780
Callithrix jacchus	100387550	CALJA19279