GlyCosmos Portal

Submissions

glycoprotein Ib platelet subunit alpha

Summary

Gene Symbol

GP1BA

Organism

Homo sapiens (human)

External Links

NCBI Gene

2811

PubChem

2811

Alliance of Genome Resources

HGNC:4439

Annotation

Keyword

3D-structure
Bernard Soulier syndrome
Cell adhesion
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Leucine-rich repeat
Phosphoprotein
Reference proteome
Repeat
Signal
Sulfation
Transmembrane helix
von Willebrand disease

Proteins

Displaying **all 2** entries
UniProt	Protein Name
L7UYB8
P07359	Antigen CD42b-alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
cell morphogenesis	IEA
megakaryocyte development	ISO NAS	16293600
positive regulation of platelet activation	IDA NAS	16293600 1939645
cell surface receptor signaling pathway	TAS	3353370
thrombin-activated receptor signaling pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

cellular process [inference]

cell activation [inference]

platelet activation

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

thrombin-activated receptor signaling pathway

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

multicellular organismal process [inference]

cell activation [inference]

platelet activation

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

thrombin-activated receptor signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte adhesion to vascular endothelial cell [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of hemostasis [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular matrix	IBA
external side of plasma membrane	IDA	19443707
membrane	IDA	15297306
plasma membrane	IDA TAS	15297306
glycoprotein Ib-IX-V complex	IPI NAS	16293600 1730602

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

glycoprotein Ib-IX-V complex

glycoprotein complex [inference]

glycoprotein Ib-IX-V complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

glycoprotein Ib-IX-V complex

cellular anatomical entity [inference]

membrane

plasma membrane

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12183630 12855810 15039442 18674540 18789323 19828450 25666618 7721887
thrombin-activated receptor activity	TAS	12855810

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

proteinase-activated receptor activity [inference]

thrombin-activated receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

proteinase-activated receptor activity [inference]

thrombin-activated receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0050864	non-arteritic anterior ischemic optic neuropathy	Alliance of Genome Resources
DOID:0111056	platelet-type bleeding disorder 3	Alliance of Genome Resources
DOID:0111059	Bernard-Soulier syndrome type A2	Alliance of Genome Resources
DOID:11713	diabetic angiopathy	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:1725	peritoneum cancer	Alliance of Genome Resources
DOID:2217	Bernard-Soulier syndrome	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 28 in total

1

2

3

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14723		MGI:1333744	MOUSE06663
Rattus norvegicus	287460		RGD:1310239
Pan troglodytes	468166	9598_0:0043a0
Bos taurus	504977			BOVIN12666
Rattus norvegicus	691992			RATNO02950
Macaca mulatta	721584			MACMU14496
Taeniopygia guttata	100222319			TAEGU16087
Callithrix jacchus	100393767			CALJA36632
Pongo abelii	100459592	9601_0:004261
Sus scrofa	100515052			PIGXX03231

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements