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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Platelet glycoprotein Ib alpha chain
Summary
- UniProt ID
- P07359
- Gene Symbol
-
- GP1BA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Bernard Soulier syndrome
- Cell adhesion
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Leucine-rich repeat
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Sulfation
- Transmembrane helix
- von Willebrand disease
- Gene Ontology (GO)
| GO Term |
|---|
| membrane |
| external side of plasma membrane |
| cell surface |
| extracellular space |
| plasma membrane |
| extracellular matrix |
| glycoprotein Ib-IX-V complex |
| extracellular exosome |
| GO Term |
|---|
| thrombin-activated receptor activity |
Sequence
MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 37 | N-linked (GlcNAc...) asparagine | |||
| 175 | N-linked (GlcNAc...) asparagine | |||
| 308 | O-linked (GalNAc...) threonine | |||
| 316 | O-linked (GalNAc...) threonine |
|
||
| 320 | O-linked (GalNAc...) threonine |
|
||
| 321 | O-linked (GalNAc...) threonine |
|
||
| 328 | O-linked (GalNAc...) serine |
|
||
| 331 | O-linked (GalNAc...) threonine |
|
||
| 340 | O-linked (GalNAc...) serine |
|
||
| 341 | O-linked (GalNAc...) serine |
|
G16774YZ
G24432GW
G16150CJ
G38022PE
G42686NQ
G56784JY
G86750HK
G96921ZU
G60890ZT
G11457RF
G46748BU
G01614ZM
G12396GB
G65562ZE
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective F9 activation | Homo sapiens |
| Defective binding of VWF variant to GPIb:IX:V | Homo sapiens |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | Homo sapiens |
| GP1b-IX-V activation signalling | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Platelet Adhesion to exposed collagen | Homo sapiens |
| Platelet Aggregation (Plug Formation) | Homo sapiens |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Homo sapiens |
