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Platelet glycoprotein Ib alpha chain
Summary
- UniProt ID
- P07359
- Gene Symbol
-
- GP1BA
- Gene ID
- 2811
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Bernard Soulier syndrome
- Cell adhesion
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Leucine-rich repeat
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Sulfation
- Transmembrane helix
- von Willebrand disease
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| plasma membrane |
| membrane |
| extracellular matrix |
| external side of plasma membrane |
| cell surface |
| extracellular exosome |
| glycoprotein Ib-IX-V complex |
| GO Term |
|---|
| thrombin-activated receptor activity |
Sequence
MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 373 | O-linked (GalNAc...) serine |
|
||
| 379 | O-linked (GalNAc...) threonine |
|
||
| 380 | O-linked (GalNAc...) threonine |
|
||
| 383 | O-linked (GalNAc...) threonine |
|
||
| 385 | O-linked (GalNAc...) serine |
|
||
| 387 | O-linked (GalNAc...) threonine |
|
||
| 388 | O-linked (GalNAc...) threonine |
|
||
| 389 | O-linked (GalNAc...) serine |
|
||
| 400 | O-linked (GalNAc...) threonine |
|
||
| 401 | O-linked (GalNAc...) threonine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective F9 activation | Homo sapiens |
| Defective binding of VWF variant to GPIb:IX:V | Homo sapiens |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | Homo sapiens |
| GP1b-IX-V activation signalling | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Platelet Adhesion to exposed collagen | Homo sapiens |
| Platelet Aggregation (Plug Formation) | Homo sapiens |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050864 | non-arteritic anterior ischemic optic neuropathy | |
| DOID:0111056 | platelet-type bleeding disorder 3 | |
| DOID:0111059 | Bernard-Soulier syndrome type A2 | |
| DOID:2217 | Bernard-Soulier syndrome | |
| DOID:5844 | myocardial infarction |
