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glycoprotein Ib platelet subunit beta

Summary

Gene Symbol

GP1BB

Organism

Homo sapiens (human)

External Links

NCBI Gene

2812

PubChem

2812

Alliance of Genome Resources

HGNC:4440

Annotation

Keyword

3D-structure
Alternative splicing
Bernard Soulier syndrome
Blood coagulation
Cell adhesion
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Leucine-rich repeat
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P13224	Antigen CD42b-beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
megakaryocyte development	ISO NAS	16293600
positive regulation of platelet activation	IDA NAS	16293600 1939645
cell surface receptor signaling pathway	NAS	3353370
release of sequestered calcium ion into cytosol	IDA NAS	16293600 1939645
cell adhesion	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

cellular process [inference]

cell activation [inference]

platelet activation

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

multicellular organismal process [inference]

cell activation [inference]

platelet activation

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
glycoprotein Ib-IX-V complex	IPI NAS	16293600 1730602

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

glycoprotein Ib-IX-V complex

glycoprotein complex [inference]

glycoprotein Ib-IX-V complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

glycoprotein Ib-IX-V complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11943773 18674540 18789323 4044584
identical protein binding	IPI	18674540
transmembrane signaling receptor activity	NAS	3353370

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2217	Bernard-Soulier syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14724		MGI:107852	MOUSE18363
Rattus norvegicus	116727		RGD:621050	RATNO04039
Danio rerio	798998		ZFIN:ZDB-GENE-081104-406	DANRE43267
Sus scrofa	100155101			PIGXX07439
Taeniopygia guttata	100218998			TAEGU05806
Pongo abelii	100453789	9601_0:005005		PONAB22069
Xenopus tropicalis	100491142		Xenbase:XB-GENE-5829006
Cavia porcellus	100735782			CAVPO03527
Felis catus	101080743			FELCA28489
Octodon degus	101586597			OCTDE05736