GlyCosmos Portal

Submissions

glypican 1

Summary

Gene Symbol

GPC1

Aliases

glypican
glypican proteoglycan 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2817

HGNC

4449

KEGG Gene ID

hsa:2817

PubChem

2817

Alliance of Genome Resources

HGNC:4449

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Copper
Direct protein sequencing
Disulfide bond
Endosome
GPI-anchor
Heparan sulfate
Reference proteome
S-nitrosylation
Secreted
Signal
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384NPH9
P35052

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cell migration	IBA
Schwann cell differentiation	ISS
myelin assembly	ISS
negative regulation of fibroblast growth factor receptor signaling pathway	IBA ISS
positive regulation of skeletal muscle cell differentiation	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

catabolic process [inference]

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfur compound catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

heparan sulfate proteoglycan catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfur compound catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

regulation of skeletal muscle cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

regulation of skeletal muscle cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of skeletal muscle cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular matrix	ISS
endosome	IEA
cytosol	IDA
extracellular region	HDA	27068509
Golgi lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

Golgi lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
laminin binding	ISS
copper ion binding	IDA	12732622
fibroblast growth factor binding	IBA ISS
protein binding	IPI	30282023

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

fibroblast growth factor binding

laminin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

extracellular matrix binding [inference]

laminin binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000063660

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08107

Name

glypican 1

References

11474185

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050894	ameloblastoma	DisGeNET
DOID:0060248	Simpson-Golabi-Behmel syndrome type 1	DisGeNET
DOID:0060870	isolated growth hormone deficiency	DisGeNET
DOID:0060872	isolated growth hormone deficiency type II	DisGeNET
DOID:0060873	isolated growth hormone deficiency type IA	DisGeNET
DOID:0060874	isolated growth hormone deficiency type IB	DisGeNET
DOID:0060875	isolated growth hormone deficiency type III	DisGeNET

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181658	WB:WBGene00001687
Drosophila melanogaster	39596	FB:FBgn0041604
Callorhinchus milii	103189052		CALMI00744
Latimeria chalumnae	102366887		LATCH08811
Danio rerio	393995	ZFIN:ZDB-GENE-040426-1306
Danio rerio	553367	ZFIN:ZDB-GENE-051120-147
Xenopus laevis	108717114	Xenbase:XB-GENE-6487297
Xenopus laevis	108718180	Xenbase:XB-GENE-17335378
Xenopus tropicalis	779769	Xenbase:XB-GENE-964661
Chrysemys picta bellii	101933264		CHRPI02379

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements