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Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Glypican-1
Summary
- UniProt ID
- P35052
- Gene Symbol
-
- GPC1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Copper
- Direct protein sequencing
- Disulfide bond
- Endosome
- GPI-anchor
- Heparan sulfate
- Reference proteome
- S-nitrosylation
- Secreted
- Signal
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| cytosol |
| membrane raft |
| nucleoplasm |
| endosome |
| Golgi lumen |
| cell surface |
| side of membrane |
| lysosomal lumen |
| extracellular space |
| plasma membrane |
| GO Term |
|---|
| fibroblast growth factor binding |
| copper ion binding |
| laminin binding |
Sequence
MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 71 |
|
|||
| 79 | N-linked (GlcNAc...) asparagine | |||
| 116 | N-linked (GlcNAc...) asparagine | |||
| 156 |
|
|
||
| 409 |
|
|||
| 486 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 488 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 490 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 509 |
|
|||
| 510 |
|
G49108TO
G83460ZZ
G66621EA
G27058EU
G41071NU
G91636VS
G59626AS
G80920RR
G65184UU
G42124LM
G90659AW
G62765YT
G72790NZ
G10486CT
G95865ZB
G49955PK
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| Attachment and Entry | Homo sapiens |
| Cell surface interactions at the vascular wall | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | Homo sapiens |
| Defective EXT2 causes exostoses 2 | Homo sapiens |
| HS-GAG biosynthesis | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0050819 | obsolete Matthew-Wood syndrome | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0050894 | ameloblastoma | |
| DOID:0060248 | Simpson-Golabi-Behmel syndrome type 1 | |
| DOID:0060870 | isolated growth hormone deficiency | |
| DOID:0060872 | isolated growth hormone deficiency type II | |
| DOID:0060873 | isolated growth hormone deficiency type IA | |
| DOID:0060874 | isolated growth hormone deficiency type IB | |
| DOID:0060875 | isolated growth hormone deficiency type III |
