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ADAM metallopeptidase with thrombospondin type 1 motif 2

Summary

Gene Symbol

ADAMTS2

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 282401
PubChem: 282401

Annotation

Keyword

Cleavage on pair of basic residues
Collagen degradation
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P79331	Procollagen I N-proteinase Procollagen I/II amino propeptide-processing enzyme Procollagen N-endopeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
proteolysis	IEA	22301074
collagen biosynthetic process
collagen fibril organization
collagen catabolic process
extracellular matrix organization	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

catabolic process [inference]

collagen catabolic process

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

supramolecular fiber organization

collagen fibril organization

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix
collagen-containing extracellular matrix	IEA	22301074
extracellular region

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA	22301074
metalloendopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A disintegrin and metalloproteinase with thrombospondin motifs

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 8** entries
InterPro
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **11 - 20** of 65 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cavia porcellus	100721564		CAVPO24358
Pan paniscus	100979430		PANPA33329
Papio anubis	101013940		PAPAN31643
Saimiri boliviensis boliviensis	101039904		SAIBB39000
Felis catus	101096945		FELCA01282
Ovis aries	101120574	9940_0:001c4a	SHEEP15990
Gorilla gorilla gorilla	101142866		GORGO33979
Tursiops truncatus	101339059	9739_0:00116a	TURTR13537
Jaculus jaculus	101597045		JACJA18419
Melopsittacus undulatus	101874689		MELUD09748