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FIC domain protein adenylyltransferase

Summary

Gene Symbol

Ficd

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

288741

PubChem

288741

Alliance of Genome Resources

RGD:1359391

Annotation

Keyword

ATP-binding
Endoplasmic reticulum
Glycoprotein
Hydrolase
Magnesium
Manganese
Membrane
Nucleotidyltransferase
Phosphoprotein
Reference proteome
Repeat
Signal-anchor
TPR repeat
Transmembrane helix
Unfolded protein response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6AY47	AMPylator FICD De-AMPylase FICD FIC domain-containing protein
A6J228	AMPylator FICD FIC domain-containing protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
regulation of IRE1-mediated unfolded protein response	IEA ISO ISS
protein deadenylylation	ISS
response to unfolded protein	IEA
protein adenylylation	IEA ISO ISS
response to endoplasmic reticulum stress	IEA ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

macromolecule modification [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein nucleotidylation [inference]

protein adenylylation

protein denucleotidylation [inference]

protein deadenylylation

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

regulation of IRE1-mediated unfolded protein response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane
endoplasmic reticulum membrane	IEA ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein-folding chaperone binding	ISO ISS
protein adenylylhydrolase activity	ISS
identical protein binding	ISO
Hsp70 protein binding	IEA ISO
ATP binding	IEA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

AMPylase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

protein adenylylhydrolase activity

catalytic activity, acting on a protein [inference]

protein adenylylhydrolase activity

binding [inference]

protein binding [inference]

heat shock protein binding [inference]

Hsp70 protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein-folding chaperone binding

Hsp70 protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Zinc finger, RING-type

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
AMPylase activity
ATP binding
nucleotide binding
nucleotidyltransferase activity
transferase activity

Displaying **all 4** entries
InterPro
Fido domain-containing protein
Fido domain
Fido-like domain superfamily
Tetratricopeptide-like helical domain superfamily

Rhea

RHEA:54288

ATP

diphosphate

Enzyme

2.7.7.108

PMID

RHEA:58120

ATP

diphosphate

Enzyme

2.7.7.108

PMID

30270044

RHEA:54292

ATP

diphosphate

Enzyme

2.7.7.108

PMID

Ortholog

Displaying entries **1 - 10** of **124** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	11153		HGNC:18416	HUMAN15194
Drosophila melanogaster	33897		FB:FBgn0263278
Caenorhabditis elegans	177990		WB:WBGene00014004
Mus musculus	231630	10090_1:0019f2	MGI:1098550	MOUSE44982
Danio rerio	334648		ZFIN:ZDB-GENE-030131-6588	DANRE36816
Bos taurus	505923			BOVIN09714
Macaca mulatta	706780			MACMU02940
Pan troglodytes	743566			PANTR06806
Monodelphis domestica	100025324			MONDO18677
Equus caballus	100059882			HORSE41743

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OrthoDB (Group)

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Acknowledgements