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protein tyrosine phosphatase, receptor type N2

Summary

Gene Symbol

Ptprn2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29714

PubChem

29714

Alliance of Genome Resources

RGD:61904

Annotation

Keyword

Acetylation
Cytoplasmic vesicle
Glycoprotein
Methylation
Phospholipid metabolism
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q63475	PTP NE-6 Phogrin
A6KDL9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
negative regulation of GTPase activity	IDA	16413169
insulin secretion involved in cellular response to glucose stimulus	IBA IEA ISO ISS
neurotransmitter secretion	IEA ISO ISS
protein dephosphorylation	IEA
regulation of secretion	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of localization in cell [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

negative regulation of biological process [inference]

negative regulation of GTPase activity

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

negative regulation of GTPase activity

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	EXP IDA IEA ISO ISS	23622064
secretory granule membrane	IEA ISO ISS
secretory granule	IBA IDA ISO	8663434
presynapse	IDA	27630542
terminal bouton	IDA	9714834

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

cell junction [inference]

synapse

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

presynapse

terminal bouton

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16413169
protein tyrosine phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

receptor-type tyrosine-protein phosphatase N2

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 4** entries
Gene Ontology
dephosphorylation
insulin secretion involved in cellular response to glucose stimulus
protein tyrosine phosphatase activity
regulation of secretion

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
endoplasmic reticulum lumen	PMID:8663434
terminal bouton	PMID:9714834
secretory granule	PMID:8663434

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:11716	prediabetes syndrome	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5799		HGNC:9677	HUMAN92278
Mus musculus	19276	10090_1:003e07	MGI:107418	MOUSE08661
Drosophila melanogaster	33277		FB:FBgn0031294
Caenorhabditis elegans	175807		WB:WBGene00002048
Danio rerio	325033		ZFIN:ZDB-GENE-030131-3758
Equus caballus	100067294			HORSE33167
Callithrix jacchus	100390644			CALJA43898
Pongo abelii	100438634			PONAB33192
Nomascus leucogenys	100580378			NOMLE07497
Cavia porcellus	100723726	10141_0:00248c