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Guidelines

MIRAGE

protein tyrosine phosphatase, receptor type N2

Summary

Gene Symbol

Ptprn2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29714

PubChem

29714

Alliance of Genome Resources

RGD:61904

Annotation

Keyword

Acetylation
Cytoplasmic vesicle
Glycoprotein
Methylation
Phospholipid metabolism
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q63475	PTP NE-6 Phogrin
A6KDL9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
protein dephosphorylation
lipid metabolic process	IEA
neurotransmitter secretion	ISS
neurotransmitter secretion	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of localization in cell [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

negative regulation of biological process [inference]

negative regulation of GTPase activity

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

negative regulation of GTPase activity

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA	8663434
secretory granule	ISO
secretory granule	IDA	8663434
secretory granule	IBA
secretory granule membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

cell junction [inference]

synapse

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

terminal bouton

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IEA
non-membrane spanning protein tyrosine phosphatase activity	IEA
protein binding	IPI	16413169
protein tyrosine phosphatase activity, metal-dependent	IEA
histone H2AXY142 phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aminopeptidase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
Peptidase M18, domain 2
Peptidase M18

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
endoplasmic reticulum lumen	PMID:8663434
terminal bouton	PMID:9714834
secretory granule	PMID:8663434

Ortholog

Displaying entries **1 - 10** of 21 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	5798	FB:FBgn0031294
Homo sapiens	5799	ZFIN:ZDB-GENE-030131-3758	HUMAN92278
Mus musculus	19276	ZFIN:ZDB-GENE-030131-3758	MOUSE08661
Danio rerio	29714	ZFIN:ZDB-GENE-030131-3758
Drosophila melanogaster	116660	FB:FBgn0031294
Danio rerio	175807	ZFIN:ZDB-GENE-030131-3758
Equus caballus	100067294		HORSE33167
Callithrix jacchus	100390644		CALJA43898
Pongo abelii	100438634		PONAB33192
Nomascus leucogenys	100580378		NOMLE07497

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Last updated: April 7, 2025