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hemoglobin subunit beta

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3043

PubChem

3043

Alliance of Genome Resources

HGNC:4827

Annotation

Keyword

3D-structure
Acetylation
Congenital dyserythropoietic anemia
Direct protein sequencing
Disease variant
Glycation
Heme
Hypotensive agent
Oxygen transport
Phosphoprotein
Pyruvate
Reference proteome
S-nitrosylation
Vasoactive

Proteins

Displaying **all 2** entries
UniProt	Protein Name
D9YZU5
P68871	Beta-globin Hemoglobin beta chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nitric oxide transport	IDA NAS	8292032
blood vessel diameter maintenance	IEA
response to hydrogen peroxide	IDA	19740759
hydrogen peroxide catabolic process	IBA IDA	19740759
cellular oxidant detoxification	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

renal system process [inference]

renal absorption

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

localization [inference]

establishment of localization [inference]

transport [inference]

gas transport [inference]

organic substance transport [inference]

one-carbon compound transport [inference]

carbon dioxide transport

nitrogen compound transport [inference]

nitric oxide transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of biological quality [inference]

regulation of blood pressure

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
haptoglobin-hemoglobin complex	IBA IDA	19740759
tertiary granule lumen	TAS
endocytic vesicle lumen	TAS
extracellular region	TAS
blood microparticle	HDA	22516433

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

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GO Term	Evidence Code	PMID
protein binding	IPI	10390349 10930828 11159543 11724557 1552945 15835899 16169070 25502805 28514442 28665412 29997244 30833564 31515488 32296183 33961781 37398436 6683087 9441940 9830011 9894000
hemoglobin binding	IDA	1512262
metal ion binding	IEA
oxygen binding	IBA IDA	11747442 28066926
haptoglobin binding	IBA IDA	19740759

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

protein binding

hemoglobin binding

hemoglobin alpha binding

haptoglobin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

molecular carrier activity [inference]

oxygen carrier activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Hemoglobin subunit beta

Functional Category

H: Coenzyme transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
haptoglobin binding
heme binding
hemoglobin alpha binding
hydrogen peroxide catabolic process
organic acid binding
oxygen binding
oxygen transport

Displaying **all 4** entries
InterPro
Globin-like superfamily
Globin/Protoglobin
Globin
Hemoglobin, beta-type

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0080770	autosomal dominant beta thalassemia	Alliance of Genome Resources
DOID:0080773	delta beta-thalassemia	Alliance of Genome Resources
DOID:0111363	Heinz body anemia	Alliance of Genome Resources
DOID:0111632	familial erythrocytosis 6	Alliance of Genome Resources
DOID:10923	sickle cell anemia	Alliance of Genome Resources
DOID:1099	alpha thalassemia	Alliance of Genome Resources
DOID:12241	beta thalassemia	Alliance of Genome Resources
DOID:12365	malaria	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1584	acute chest syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **100** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15129	MGI:96021	MOUSE56988
Mus musculus	15130	MGI:96022	MOUSE56988
Rattus norvegicus	24440	RGD:2783	RATNO21248
Danio rerio	30216		DANRE31960
Drosophila melanogaster	41930	FB:FBgn0027657
Rattus norvegicus	361619		RATNO21248
Xenopus tropicalis	394453	Xenbase:XB-GENE-5912896
Mus musculus	436003	MGI:96025
Danio rerio	445037	ZFIN:ZDB-GENE-040801-164
Xenopus tropicalis	448249	Xenbase:XB-GENE-5808005