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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
major histocompatibility complex, class I, A
Summary
- Gene Symbol
-
- HLA-A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Immunoglobulin domain
- Innate immunity
- MHC I
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Proteins
Gene Ontology (GO)
GO Hierarchy
biological process
immune system process [inference]
antigen processing and presentation [inference]
antigen processing and presentation of endogenous antigen [inference]
antigen processing and presentation of peptide antigen [inference]
antigen processing and presentation of peptide antigen via MHC class I [inference]
antigen processing and presentation of endogenous peptide antigen [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of macromolecule metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell killing [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| Golgi medial cisterna | ||
| membrane | ||
| Golgi apparatus | ||
| endoplasmic reticulum membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| beta-2-microglobulin binding | ||
| T cell receptor binding | ||
| protein binding | ||
| TAP complex binding | ||
| signaling receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- HLA class I histocompatibility antigen, A alpha chain-like
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- V: Defense mechanisms
| InterPro |
|---|
| Immunoglobulin C1-set |
| MHC class I-like antigen recognition-like |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050426 | Stevens-Johnson syndrome | |
| DOID:0081267 | graft-versus-host disease | |
| DOID:10591 | pre-eclampsia | |
| DOID:1245 | vulva cancer | |
| DOID:12918 | thromboangiitis obliterans | |
| DOID:13099 | Moyamoya disease | |
| DOID:13141 | uveitis | |
| DOID:1761 | Melkersson-Rosenthal syndrome | |
| DOID:2508 | Takayasu's arteritis | |
| DOID:3526 | cerebral infarction |
Ortholog
