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MIRAGE
HLA class I histocompatibility antigen, A alpha chain

Summary
UniProt ID
P04439
Gene Symbol
  • HLA-A
  • HLAA
Gene ID
3105
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P04439
PubChem
P04439
The O-GlcNAc Database
P04439
RaftProt
P04439
O-GlcNAcAtlas
P04439
Re-Glyco
P04439
Annotation
Keyword
  • 3D-structure
  • Adaptive immunity
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Endoplasmic reticulum
  • Glycoprotein
  • Host-virus interaction
  • Immunoglobulin domain
  • Innate immunity
  • MHC I
  • Phosphoprotein
  • Reference proteome
  • Signal
  • Sulfation
  • Transmembrane helix
  • Ubl conjugation
Gene Ontology (GO)
Displaying entries 1 - 10 of 19 in total
GO Term
extracellular space
plasma membrane
membrane
Golgi membrane
endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
Golgi medial cisterna
external side of plasma membrane
cell surface
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
110 N-linked (GlcNAc...) asparagine
112
359
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 9 entries
Pathway Name Organism
Antigen Presentation: Folding, assembly and peptide loading of class I MHC Homo sapiens
E3 ubiquitin ligases ubiquitinate target proteins Homo sapiens
ER-Phagosome pathway Homo sapiens
Endosomal/Vacuolar pathway Homo sapiens
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens
Interferon alpha/beta signaling Homo sapiens
Interferon gamma signaling Homo sapiens
Nef mediated downregulation of MHC class I complex cell surface expression Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses Homo sapiens
Disease
Displaying entries 1 - 10 of 12 in total
DO ID Disease Name Source
DOID:0050426 Stevens-Johnson syndrome
DOID:10591 pre-eclampsia
DOID:1245 vulva cancer
DOID:12918 thromboangiitis obliterans
DOID:13099 Moyamoya disease
DOID:13141 uveitis
DOID:2508 Takayasu's arteritis
DOID:3526 cerebral infarction
DOID:399 tuberculosis
DOID:419 scleroderma
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025