E3 ubiquitin ligases ubiquitinate target proteins

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PRKDCRNF144A:PRKDC:Ub:UBE2L3Ub:UBE2L3RNF144APRKDC_HUMANUBE2L3Ub:UBE2NRNF152:RRAGA:GDP:Ub:UBE2NRRAGA:GDPRNF152UBE2NK63polyUb-K142,K220,K230,K244-RRAGA:GDPRNF181RNF181:BCL10:Ub:E2Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2NBCL10UBE2D1,UBE2D2,UBE2D3,UBE2E1,UBE2NBCL10_HUMANRNF20:RNF40PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2BPAF1CUb:RAD6WACHistone HIST1H2BUBE2A,BHIST1H2BA-D,H,J-OUb:UBC13:MMS2SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2RAD18:UBE2BSHPRHMonoUb:K164-PCNA homotrimerK63polyUb-K164-PCNA homotrimerUBC13:MMS2HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2HLTFUS11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2K48polyUb-HLA A-2,A-3,B-60UBE2J2-1Ub:UBE2J2TMEM129:DERL1:VIMP:VCP:UBE2J2US11Ub:UBE2D1,2,3PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12UBE2D1,2,3PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14US11:HLATMEM129:DERL1:VIMP:VCP:Ub:UBE2J2
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 26 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O60814 Histone H2B type 1-K
  • H2BC12
  • H2BFT
  • HIRIP1
  • HIST1H2BK
view
O75150 E3 ubiquitin-protein ligase BRE1B
  • BRE1B
  • KIAA0661
  • RNF40
view
O75381 Peroxisomal membrane protein PEX14
  • PEX14
view
P04439 HLA class I histocompatibility antigen, A alpha chain
  • HLA-A
  • HLAA
view
P06899 Histone H2B type 1-J
  • H2BC11
  • H2BFR
  • HIST1H2BJ
view
P09727 Unique short US11 glycoprotein
  • US11
view
P12004 Proliferating cell nuclear antigen
  • PCNA
view
P23527 Histone H2B type 1-O
  • H2BC17
  • H2BFH
  • H2BFN
  • HIST1H2BO
view
P33778 Histone H2B type 1-B
  • H2BC3
  • H2BFF
  • HIST1H2BB
view
P55072 Transitional endoplasmic reticulum ATPase
  • HEL-220
  • HEL-S-70
  • VCP
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025