Interferon alpha/beta signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
IFNAR2:JAK1:STAT2IFNA/B:IFNAR2:JAK1:STAT2IFNA/BIFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2IFNAR1:TYK2ADPATPIFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1p-STAT2:p-STAT1IRF9ISGF3STAT1-1AAFp-STAT1 dimer, ISGF3p-STAT1 dimer:KPNA1KPNA1KPNB1p-STAT1 dimer:KPNA1:KPNB1ISGF3:KPNA1:KPNB1ISGF3KPNB1KPNA1p-Y701-STAT1:KPNA1:KPNB1AAFISGF3 bound to ISRE promotor elementsType I IFN-regulated genes with ISRE promoter elementsPKRXAF1PSMB8IFITM2RSAD2SAMHD1IFIT2BST2Class I MHC heavy chain (MHC HC)IP6K2ISG20EGR1IFI6IFITM1IFI35IRF 1-9OAS proteinsISG15IFI27IFIT5IFIT1RNASELMx GTPasesADARIFITM3GBP2IFIT3RNASEL dimerABCE1:RNASEL dimerABCE1STAT2STAT1IFNAR2:JAK1:STAT2:type 1 interferon analogstype 1 interferon analogsIFNAR2:JAK1:STAT2:JAK1,2 inhibitorsJAK1,2 inhibitorsTYK2 inhibitorsIFNAR1:TYK2:TYK2 inhibitors
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025