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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
HLA class I histocompatibility antigen, A alpha chain
Summary
- UniProt ID
- P04439
- Gene Symbol
-
- HLA-A
- HLAA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Immunoglobulin domain
- Innate immunity
- MHC I
- Phosphoprotein
- Reference proteome
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| Golgi apparatus |
| Golgi medial cisterna |
| external side of plasma membrane |
| cell surface |
| extracellular space |
| plasma membrane |
| MHC class I protein complex |
Sequence
MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 110 | N-linked (GlcNAc...) asparagine | |||
| 112 |
|
|||
| 359 |
|
G77669RF
G04854VP
G92135MA
G45395BF
G85554PZ
G20706XG
G40926MX
G49642SA
G26330YA
G40574BA
G87389XI
G36442WJ
G76295SF
G15664MX
G27126ED
G04657PL
G83460ZZ
G41071NU
G49018RC
G72747WU
G70101JE
G80920RR
G73968GN
G02886BB
G62765YT
G64527OM
G54010QB
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | Homo sapiens |
| E3 ubiquitin ligases ubiquitinate target proteins | Homo sapiens |
| ER-Phagosome pathway | Homo sapiens |
| Endosomal/Vacuolar pathway | Homo sapiens |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Homo sapiens |
| Interferon alpha/beta signaling | Homo sapiens |
| Interferon gamma signaling | Homo sapiens |
| Nef mediated downregulation of MHC class I complex cell surface expression | Homo sapiens |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | Homo sapiens |
