Interferon gamma signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
SMAD7 geneSMAD7IFNG dimerIFNG:IFNGR complexIFNGR1:JAK1:INFGR2:JAK2IFNG dimer:IFNG inhibitorsIFNG inhibitorsATPIFNG:IFNGR1:JAK1:IFNGR2:p-JAK2ADPIFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2p-S32,S36-YBX1YBX1p-S32,S36-YBX1STAT1-1STAT1 bound to p-IFNGR1p-STAT1(Y701) bound to p-IFNGR1p-STAT1 dimer bound to p-IFNGR1p-STAT1:p-STAT1 dimerp-STAT1 homodimerGAF bound to GAS promoter elementIFNG-regulated genes with GAS promoter elementsIRF 1-9OAS proteinsB2M(21-119)CIITAMT2AGILTSP100MHC class II alpha/beta dimerGBPClass I MHC heavy chain (MHC HC)IFN-gamma upregulated CAMsIFNG induced TRIMsPMLFCGRAPTAFRIFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitorsJAK1,2 inhibitors
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 4 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_002323 P05362 Intercellular adhesion molecule 1 view
GL_002347 P13591 Neural cell adhesion molecule 1 view
GL_002758 P01911 HLA class II histocompatibility antigen, DRB1 beta chain view
GL_002832 P01903 HLA class II histocompatibility antigen, DR alpha chain view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025