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major histocompatibility complex, class II, DR beta 3

Summary

Gene Symbol

HLA-DRB3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3125

PubChem

3125

Alliance of Genome Resources

HGNC:4951

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasmic vesicle
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Lysosome
MHC II
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P79483	MHC class II antigen DRB3
A0A4D6G1L1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA IDA	19531622 32341563
positive regulation of T cell mediated immune response to tumor cell	IDA	30282837
positive regulation of immune response	IBA
T cell receptor signaling pathway	IDA	32341563
peptide antigen assembly with MHC class II protein complex	IBA

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

dendritic cell antigen processing and presentation [inference]

myeloid dendritic cell antigen processing and presentation

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of CD4-positive, alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of response to tumor cell [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of CD4-positive, alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of CD4-positive, alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
transport vesicle membrane	TAS
autolysosome membrane	IEA
MHC class II protein complex	IBA ISS	20356827
endocytic vesicle membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class II protein complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

transport vesicle membrane

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

trans-Golgi network membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

autophagosome membrane [inference]

autolysosome membrane

lytic vacuole membrane [inference]

lysosomal membrane

autolysosome membrane

endosome membrane [inference]

late endosome membrane

transport vesicle membrane

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32814053
MHC class II protein complex binding	IBA
MHC class II receptor activity	NAS	6414998
peptide antigen binding	IBA IDA ISS	17583734 18697946 20356827

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class II protein complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

MHC class II receptor activity

immune receptor activity [inference]

MHC class II receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080822	aspirin-induced respiratory disease	Alliance of Genome Resources
DOID:12361	Graves' disease	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 13 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	14969	MGI:95901
Rattus norvegicus	24981	RGD:1595922
Danio rerio	30762	ZFIN:ZDB-GENE-980526-200
Rattus norvegicus	294270	RGD:1593282
Danio rerio	326022	ZFIN:ZDB-GENE-030131-4747
Danio rerio	368615	ZFIN:ZDB-GENE-030616-319
Danio rerio	368703	ZFIN:ZDB-GENE-030616-99
Danio rerio	368846	ZFIN:ZDB-GENE-030616-396
Mus musculus	381091	MGI:95902
Danio rerio	563286	ZFIN:ZDB-GENE-030616-171

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements