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apurinic/apyrimidinic endodeoxyribonuclease 1

Summary

Gene Symbol

APEX1

Organism

Homo sapiens (human)

External Links

NCBI Gene

328

PubChem

328

Alliance of Genome Resources

HGNC:587

Annotation

Keyword

3D-structure
Acetylation
Activator
Cleavage on pair of basic residues
Cytoplasm
DNA recombination
DNA repair
DNA-binding
Direct protein sequencing
Disulfide bond
Endonuclease
Endoplasmic reticulum
Exonuclease
Magnesium
Manganese
Metal-binding
Mitochondrion
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repressor
S-nitrosylation
Transcription regulation
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P27695	APEX nuclease Apurinic-apyrimidinic endonuclease 1 DNA-(apurinic or apyrimidinic site) endonuclease Redox factor-1
Q5TZP7	APEX nuclease Apurinic-apyrimidinic endonuclease 1 Redox factor-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

1

2

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GO Term	Evidence Code	PMID
regulation of mRNA stability	IMP	19401441
cell redox homeostasis	IEA
telomere maintenance via base-excision repair	IDA	24703901
base-excision repair	IBA IDA	8932386
DNA repair	IDA	1627644 9560228

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

DNA repair

base-excision repair

telomere maintenance via base-excision repair

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

telomere maintenance via base-excision repair

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

transcription initiation-coupled chromatin remodeling [inference]

positive regulation of gene expression via CpG island demethylation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

telomere maintenance via base-excision repair

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

telomere maintenance via base-excision repair

telomere maintenance in response to DNA damage [inference]

telomere maintenance via base-excision repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

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GO Term	Evidence Code	PMID
nuclear speck	IDA	17148573
chromosome, telomeric region	IC	24703901
ribosome	TAS	12524539
nucleoplasm	IDA TAS	17148573
mitochondrion	HTP IDA	20231292 34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

perinuclear region of cytoplasm

chromosomal region [inference]

chromosome, telomeric region

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GO Term	Evidence Code	PMID
protein binding	IPI	11118054 11809897 12524539 15518571 15942031 18809583 19188445 19465398 19505873 19934257 20231292 20696907 20808282 20856196 26760506 28514442 32911434 33961781 8621488 9108029 9207062
3'-5' exonuclease activity	IDA TAS	11286553 11832948
DNA-(abasic site) binding	IMP	9804798
phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands	IDA	1627644
DNA binding	IDA	11286553

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

endodeoxyribonuclease activity

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

class II DNA-(apurinic or apyrimidinic site) endonuclease activity

site-specific endodeoxyribonuclease activity, specific for altered base

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

class II DNA-(apurinic or apyrimidinic site) endonuclease activity

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

exonuclease activity [inference]

phosphodiesterase I activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

3'-5' exonuclease activity

3'-5'-DNA exonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

class II DNA-(apurinic or apyrimidinic site) endonuclease activity

site-specific endodeoxyribonuclease activity, specific for altered base

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity [inference]

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class II DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

class II DNA-(apurinic or apyrimidinic site) endonuclease activity

site-specific endodeoxyribonuclease activity, specific for altered base

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

double-stranded DNA exodeoxyribonuclease activity

double-stranded DNA 3'-5' DNA exonuclease activity

DNA N-glycosylase activity [inference]

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

chromatin binding [inference]

chromatin DNA binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

damaged DNA binding

DNA-(abasic site) binding

double-stranded DNA binding [inference]

double-stranded telomeric DNA binding

chromatin DNA binding

sequence-specific DNA binding [inference]

telomeric DNA binding [inference]

double-stranded telomeric DNA binding

RNA binding

transcription regulator activity [inference]

transcription coregulator activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA-

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0080016	spina bifida	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:13129	severe pre-eclampsia	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:2893	cervix carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11792	MGI:88042	MOUSE13257
Rattus norvegicus	25142	RGD:2126
Drosophila melanogaster	33500	FB:FBgn0004584
Rattus norvegicus	79116		RATNO09352
Caenorhabditis elegans	173069	WB:WBGene00001372
Bos taurus	281630		BOVIN00867
Xenopus tropicalis	394929	Xenbase:XB-GENE-977072
Danio rerio	406730	ZFIN:ZDB-GENE-040426-2761	DANRE33213
Xenopus laevis	432324	Xenbase:XB-GENE-977079
Pan troglodytes	465200		PANTR08199

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements