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polycystic kidney disease 2-like 1

Summary

Gene Symbol

Pkd2l1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

329064

PubChem

329064

Alliance of Genome Resources

MGI:1352448

Annotation

Keyword

3D-structure
Calcium channel
Cell membrane
Cilium
Coiled coil
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Metal-binding
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A2A259	Polycystic kidney disease 2-like 1 protein Polycystin-2 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
smoothened signaling pathway	IMP	24336288
inorganic cation transmembrane transport	IDA ISO	28904867
monoatomic cation transport	IDA	16891422
calcium ion transmembrane transport	IEA
cellular response to pH	IDA	28904867

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

cellular response to acidic pH

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

response to mechanical stimulus [inference]

detection of mechanical stimulus

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH [inference]

cellular response to acidic pH

cellular response to pH

cellular response to acidic pH

response to water

detection of abiotic stimulus [inference]

detection of mechanical stimulus

response to mechanical stimulus [inference]

detection of mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to pH

cellular response to acidic pH

response to chemical [inference]

response to acid chemical [inference]

response to water

response to organic substance [inference]

response to water

response to inorganic substance [inference]

response to water

response to oxygen-containing compound [inference]

response to water

response to salt [inference]

response to water

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

detection of abiotic stimulus [inference]

detection of mechanical stimulus

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste

detection of chemical stimulus involved in sensory perception of sour taste

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste

detection of chemical stimulus involved in sensory perception of sour taste

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

cellular response to acidic pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
ciliary membrane	IEA
cytosol	IEA ISO
cation channel complex	IDA	16891422

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex

calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex

calcium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

non-motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

non-motile cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
cytoskeletal protein binding	ISO
calcium-activated cation channel activity	ISO
monoatomic cation channel activity	IDA IPI ISO	15548533 16891422 28904867
alpha-actinin binding	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

calcium channel activity

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

monoatomic cation transmembrane transporter activity

monoatomic cation channel activity

calcium channel activity

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

calcium channel activity

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

monoatomic ion-gated channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

binding [inference]

protein binding

cytoskeletal protein binding

actinin binding [inference]

alpha-actinin binding

muscle alpha-actinin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

taste receptor activity [inference]

sour taste receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

polycystic kidney disease 2-like 1 protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 10** entries
Gene Ontology
calcium channel activity
calcium ion binding
calcium ion transmembrane transport
calcium ion transport
calcium-activated potassium channel activity
detection of mechanical stimulus
metal ion binding
monoatomic ion transport
muscle alpha-actinin binding
sodium channel activity

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110859	polycystic kidney disease 2	Alliance of Genome Resources
DOID:898	autosomal dominant polycystic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of **106** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ictalurus punctatus	108263119		ICTPU26707
Rhinopithecus bieti	108535073		RHIBE07655
Cyprinus carpio carpio	109092135		CYPCA66242
Cyprinus carpio carpio	109092136		CYPCA79434
Castor canadensis	109681483	51338_0:000a52
Mus caroli	110285656	10089_0:00498d
Mus pahari	110331862	10093_0:00002f
Meriones unguiculatus	110552980	10047_0:002084
Ictidomys tridecemlineatus	110597449	43179_0:003adc
Seriola dumerili	111220770		SERDU12226