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heat shock protein family A (Hsp70) member 4

Summary

Gene Symbol

HSPA4

Organism

Homo sapiens (human)

External Links

NCBI Gene

3308

PubChem

3308

Alliance of Genome Resources

HGNC:5237

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Methylation
Phosphoprotein
Reference proteome
Stress response

Proteins

Displaying 1 entry
UniProt	Protein Name
P34932	HSP70RY Heat shock 70-related protein APG-2 Heat shock protein family H member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein folding	IBA
protein insertion into mitochondrial outer membrane	IDA	15644312
response to unfolded protein	NAS	8335910
chaperone-mediated protein complex assembly	IDA	15644312

GO Hierarchy

biological process

cellular process [inference]

protein folding

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

outer mitochondrial membrane organization [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular component assembly [inference]

protein-containing complex assembly [inference]

chaperone-mediated protein complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

chaperone-mediated protein complex assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

outer mitochondrial membrane organization [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of localization [inference]

transport [inference]

mitochondrial transport [inference]

protein insertion into mitochondrial outer membrane

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	IEA
nucleus	IBA
cytosol	IBA IDA	21231916
extracellular exosome	HDA IDA	20458337 21276792

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20029029 22990239 24658140 25416956 29568061 30021884 31980649 32296183 33961781
ATP-dependent protein folding chaperone	IEA
ATP binding	NAS	8335910
adenyl-nucleotide exchange factor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

protein folding chaperone [inference]

ATP-dependent protein folding chaperone

molecular function regulator activity [inference]

ATPase regulator activity [inference]

adenyl-nucleotide exchange factor activity

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Heat shock

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
nucleotide binding

Displaying **all 5** entries
InterPro
ATPase, nucleotide binding domain
Heat shock protein 70 family
Heat shock protein 70, conserved site
Heat shock protein 70kD, C-terminal domain superfamily
Heat shock protein 70kD, peptide-binding domain superfamily

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:11394	adult respiratory distress syndrome	Alliance of Genome Resources
DOID:12140	Chagas disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources
DOID:8577	ulcerative colitis	Alliance of Genome Resources
DOID:916	liver benign neoplasm	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15525		MGI:1342292	MOUSE05161
Drosophila melanogaster	39557		FB:FBgn0026418
Caenorhabditis elegans	176195		WB:WBGene00016250
Rattus norvegicus	266759		RGD:628878	RATNO02691
Danio rerio	334086		ZFIN:ZDB-GENE-030131-6018	DANRE07566
Danio rerio	335865		ZFIN:ZDB-GENE-040426-2832
Xenopus tropicalis	394863		Xenbase:XB-GENE-952769
Xenopus laevis	398863		Xenbase:XB-GENE-952775
Xenopus laevis	399222		Xenbase:XB-GENE-17337588
Pan troglodytes	462060	9598_0:001999