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5-hydroxytryptamine receptor 3A

Summary

Gene Symbol

HTR3A

Organism

Homo sapiens (human)

External Links

NCBI Gene

3359

PubChem

3359

Alliance of Genome Resources

HGNC:5297

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Ion channel
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4E398
P46098	5-hydroxytryptamine receptor 3 Serotonin receptor 3A Serotonin-gated ion channel receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
serotonin-gated cation-selective signaling pathway	IDA	10521471
inorganic cation transmembrane transport	IDA	17392525
excitatory postsynaptic potential	IEA
ion transmembrane transport	IBA IEA
monoatomic ion transmembrane transport	IBA IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

serotonin receptor signaling pathway

serotonin-gated cation-selective signaling pathway

ligand-gated ion channel signaling pathway [inference]

serotonin-gated cation-selective signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

serotonin receptor signaling pathway

serotonin-gated cation-selective signaling pathway

ligand-gated ion channel signaling pathway [inference]

serotonin-gated cation-selective signaling pathway

regulation of biological quality [inference]

regulation of membrane potential

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of presynaptic membrane potential

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	IEA
serotonin-activated cation-selective channel complex	IDA IPI	16116092 17392525 9950429
plasma membrane	IBA IDA TAS	9950429
neuron projection	IBA
cleavage furrow	IDA	19799413

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

serotonin receptor complex [inference]

serotonin-activated cation-selective channel complex

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

serotonin-activated cation-selective channel complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

serotonin-activated cation-selective channel complex

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

serotonin-activated cation-selective channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

serotonin-activated cation-selective channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cleavage furrow

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

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GO Term	Evidence Code	PMID
protein binding	IPI	17392525
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA
identical protein binding	IEA
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

serotonin receptor activity [inference]

serotonin-gated monoatomic cation channel activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

AcetylCholine Receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 3** entries
Gene Ontology
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 5** entries
InterPro
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:9778	irritable bowel syndrome	Alliance of Genome Resources
DOID:9975	cocaine dependence	Alliance of Genome Resources
DOID:9976	heroin dependence	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15561		MGI:96282	MOUSE60564
Rattus norvegicus	79246		RGD:61818	RATNO40683
Caenorhabditis elegans	190370		WB:WBGene00013300
Pan troglodytes	451556	9598_0:002e88		PANTR04375
Canis lupus familiaris	489399			CANLF15271
Danio rerio	571641		ZFIN:ZDB-GENE-071012-5	DANRE21280
Bos taurus	617674			BOVIN06485
Macaca mulatta	696912			MACMU11441
Caenorhabditis elegans	3564870		WB:WBGene00013338
Oryctolagus cuniculus	100009570			RABIT00599