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nervana 2

Summary

Gene Symbol

nrv2

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

33953

PubChem

33953

Alliance of Genome Resources

FB:FBgn0015777

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Signal-anchor
Sodium/potassium transport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q24048	Protein nervana 2 Sodium/potassium-dependent ATPase subunit beta-2
A4V0B5
Q1RL12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
potassium ion import across plasma membrane	IBA
monoatomic cation transport	IDA	9648860
intracellular sodium ion homeostasis	IBA
potassium ion transport	IEA
intracellular potassium ion homeostasis	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell adhesion involved in heart morphogenesis

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

tight junction organization [inference]

tight junction assembly [inference]

septate junction assembly

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

system development [inference]

respiratory system development [inference]

open tracheal system development

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of tube architecture, open tracheal system [inference]

regulation of tube size, open tracheal system

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube size, open tracheal system

regulation of tube diameter [inference]

regulation of tube diameter, open tracheal system

Displaying **all 4** entries
GO Term	Evidence Code	PMID
sodium:potassium-exchanging ATPase complex	IBA IDA IEA	9648860
septate junction	IDA	12782686 17164420
plasma membrane	HDA IDA	19000835 19317464
axon	IDA	25294943

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

sodium:potassium-exchanging ATPase complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

septate junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying 1 entry
GO Term	Evidence Code	PMID
ATPase activator activity	IBA IDA	9648860

GO Hierarchy

molecular function

molecular function regulator activity [inference]

ATPase regulator activity [inference]

ATPase activator activity

molecular function activator activity [inference]

ATPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sodium/potassium-transporting ATPase subunit beta

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATPase activator activity
intracellular sodium ion homeostasis

Displaying **all 2** entries
InterPro
Sodium/potassium-transporting ATPase subunit beta superfamily
Sodium/potassium-transporting ATPase subunit beta

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
plasma membrane	PMID:18199760 PMID:19000835 PMID:19317464
cytoplasm	FB:FBrf0161605
septate junction	PMID:12782686 PMID:17164420
axon	PMID:25294943
cell body	PMID:10452950
membrane	FB:FBrf0231198
sodium	PMID:9648860

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0040090	autoimmune gastritis	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:8929	atrophic gastritis	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 65 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Drosophila grimshawi	6561643	7222_0:00128e
Drosophila mojavensis	6576283	7230_1:00178b
Drosophila persimilis	6593456	7234_1:001b2c
Drosophila sechellia	6611444	7238_0:001a08
Drosophila virilis	6628072	7244_1:002349
Drosophila willistoni	6643791	7260_0:001776
Drosophila simulans	6731270	7240_1:000588
Danio rerio	100037383		ZFIN:ZDB-GENE-070412-1
Xenopus tropicalis	100490400		Xenbase:XB-GENE-975977
Drosophila suzukii	108020994	28584_0:000056