GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Disulfide bond
Glycoprotein
Glycosidase
Lysosome
Mucopolysaccharidosis
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P35475

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
dermatan sulfate catabolic process	IDA	24036510
heparin catabolic process	IMP	21873421
glycosaminoglycan catabolic process	TAS
disaccharide metabolic process	TAS	2470345
heparan sulfate proteoglycan catabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lysosomal lumen	TAS
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
L-iduronidase activity	IBA IDA TAS	24036510
signaling receptor binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

L-iduronidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000127415

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01217

Name

L-iduronidase [EC:3.2.1.76]

References

1946389

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R07822	3.2.1.76	G91199CQ	G34586BV

Disease

Disease Ontology

Displaying entries **11 - 20** of **174** in total

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DO ID	Disease Name	Source
DOID:0050949	autosomal recessive hypophosphatemic rickets	DisGeNET
DOID:0060215	Balo concentric sclerosis	DisGeNET
DOID:0060222	Scheie syndrome	Glyco-Disease Genes Database DisGeNET DisGeNET Alliance of Genome Resources
DOID:0060249	scoliosis	DisGeNET
DOID:0060320	inguinal hernia	DisGeNET
DOID:0060357	chylomicron retention disease	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET
DOID:0060896	Parkinson's disease 23	DisGeNET
DOID:0080001	bone disease	DisGeNET

The Human Phenotype Ontology

Displaying entries **21 - 30** of **117** in total

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HPO ID	HPO Term
HP:0000455	Broad nasal tip
HP:0000463	Anteverted nares
HP:0000470	Short neck
HP:0000488	Retinopathy
HP:0000501	Glaucoma
HP:0000546	Retinal degeneration
HP:0000574	Thick eyebrow
HP:0000691	Microdontia
HP:0000716	Depression
HP:0000772	Abnormal rib morphology

Displaying **all 6** entries
Disease ID	Disease Name
OMIM:607016	Scheie syndrome
ORPHA:93473	Hurler syndrome
ORPHA:93476	Hurler-Scheie syndrome
OMIM:607014	Hurler syndrome
OMIM:607015	Hurler-Scheie syndrome
ORPHA:93474	Scheie syndrome

PubChem Disease

GHR Health Conditions

Mucopolysaccharidosis type I

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Macaca nemestrina	105483817	MACNE34349
Papio anubis	101021298	PAPAN26594
Mandrillus leucophaeus	105532697	MANLE19436
Gorilla gorilla gorilla	101130097	GORGO31180
Pan troglodytes	461056	PANTR33112
Pongo abelii	100458752	PONAB28543
Canis lupus familiaris	100505382	CANLF12321
Felis catus	101095896	FELCA10395
Panthera leo	122218705	PANLE27245
Tursiops truncatus	101320168	TURTR01444

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements