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C-X-C motif chemokine receptor 1

Summary

Gene Symbol

CXCR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3577

PubChem

3577

Alliance of Genome Resources

HGNC:6026

Annotation

Keyword

3D-structure
Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P25024	CDw128a High affinity interleukin-8 receptor A IL-8 receptor type 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
dendritic cell chemotaxis	TAS	16621978
immune response	IBA
cell surface receptor signaling pathway	IDA	10734056
G protein-coupled receptor signaling pathway	TAS	8381837
positive regulation of cytosolic calcium ion concentration	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
external side of plasma membrane	IBA
secretory granule membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
interleukin-8 receptor activity	IDA	10734056
G protein-coupled receptor activity	TAS	8381837
chemokine receptor activity	TAS	1840701
protein binding	IPI	30384436 32296183
C-C chemokine receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
calcium-mediated signaling
chemokine-mediated signaling pathway
chemotaxis
immune response
neutrophil chemotaxis
positive regulation of cytosolic calcium ion concentration

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080784	urinary tract infection	Alliance of Genome Resources
DOID:11400	pyelonephritis	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of **127** in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100385951	CALJA38558
Pongo abelii	100461947	PONAB24791
Ailuropoda melanoleuca	100470409	AILME18394
Anolis carolinensis	100554402	ANOCA00677
Anolis carolinensis	100554601	ANOCA00678
Nomascus leucogenys	100580192	NOMLE20319
Nomascus leucogenys	100598264	NOMLE20319
Loxodonta africana	100653621	LOXAF18707
Loxodonta africana	100665573	LOXAF18708
Oreochromis niloticus	100704146	ORENI21980

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OrthoDB (Group)

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Acknowledgements