GlyCosmos Portal

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Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

35851

PubChem

35851

Alliance of Genome Resources

FB:FBgn0003892

Annotation

Keyword

Glycoprotein
Receptor
Reference proteome
Segmentation polarity protein
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P18502	Hedgehog receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
eye-antennal disc morphogenesis	IMP	11934850
regulation of apoptotic process	IGI	23018595
lipid homeostasis	IMP	18198278
determination of genital disc primordium	IMP	15893978
segment polarity determination

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber development

cellular developmental process [inference]

cell fate commitment [inference]

determination of imaginal disc primordium [inference]

determination of genital disc primordium

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

follicle cell of egg chamber development

reproductive structure development [inference]

gonad development

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

wing disc pattern formation [inference]

wing disc anterior/posterior pattern formation

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

imaginal disc lineage restriction [inference]

anterior/posterior lineage restriction, imaginal disc

developmental process [inference]

developmental process involved in reproduction [inference]

follicle cell of egg chamber development

reproductive structure development [inference]

gonad development

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

animal organ morphogenesis [inference]

imaginal disc morphogenesis [inference]

eye-antennal disc morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

Bolwig's organ morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

animal organ development [inference]

gonad development

reproductive structure development [inference]

gonad development

cellular developmental process [inference]

cell fate commitment [inference]

determination of imaginal disc primordium [inference]

determination of genital disc primordium

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of epithelial cell migration, open tracheal system

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of epithelial cell migration, open tracheal system

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of epithelial cell migration, open tracheal system

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
basal plasma membrane	IDA	28825565
fusome	IDA	8898240
plasma membrane	IBA IDA	10966113 8898240
cilium	IDA	24768000
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

basal plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

fusome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
smoothened binding	IBA
hedgehog receptor activity	IBA IEA IMP	8898207
phosphatidylinositol-4-phosphate binding	IDA	26863604
hedgehog family protein binding	IBA IDA IPI	16630821 20048000
phosphatidic acid binding	IDA	37847757

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

smoothened binding

hedgehog family protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-4-phosphate binding

phosphatidic acid binding

ion binding [inference]

anion binding [inference]

phosphatidic acid binding

cargo receptor activity [inference]

lipoprotein particle receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

hedgehog receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
endocytic vesicle	PMID:18198278
plasma membrane	PMID:10966113 PMID:8898240
fusome	PMID:8898240
cilium	PMID:24768000
basal plasma membrane	PMID:28825565

Disease

Disease Ontology

Displaying entries **1 - 10** of 21 in total

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DO ID	Disease Name	Source
DOID:0050860	colorectal adenoma	Alliance of Genome Resources
DOID:0050902	medulloblastoma	Alliance of Genome Resources
DOID:0070365	nevoid basal cell carcinoma syndrome 1	Alliance of Genome Resources
DOID:0080016	spina bifida	Alliance of Genome Resources
DOID:0110876	holoprosencephaly 7	Alliance of Genome Resources
DOID:10460	nasopharyngitis	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:12270	coloboma	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources