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insulin receptor related receptor

Summary

Gene Symbol

INSRR

Organism

Homo sapiens (human)

External Links

NCBI Gene

3645

PubChem

3645

Alliance of Genome Resources

HGNC:6093

Annotation

Keyword

3D-structure
ATP-binding
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P14616	IR-related receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase signaling pathway	NAS	10226785
epidermal growth factor receptor signaling pathway	IEA
insulin receptor signaling pathway	IBA
fibroblast growth factor receptor signaling pathway	IEA
actin cytoskeleton organization	IDA	21641549

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway [inference]

vascular endothelial growth factor receptor-1 signaling pathway

cytokine-mediated signaling pathway [inference]

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to alkaline pH

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

reproductive process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

developmental process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH [inference]

response to alkaline pH [inference]

cellular response to alkaline pH

cellular response to pH [inference]

cellular response to alkaline pH

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to alkaline pH

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to alkaline pH

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway [inference]

vascular endothelial growth factor receptor-1 signaling pathway

cytokine-mediated signaling pathway [inference]

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	NAS	10226785
plasma membrane	IBA
insulin receptor complex	IBA
axon	IBA
receptor complex	IDA	23382219

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

insulin receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

insulin receptor complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

insulin receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase activity	NAS	10226785
transmembrane receptor protein tyrosine kinase activity	IDA	21641549
GPI-linked ephrin receptor activity	IEA
transmembrane-ephrin receptor activity	IEA
epidermal growth factor receptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

collagen receptor activity [inference]

protein tyrosine kinase collagen receptor activity

neurotrophin receptor activity [inference]

brain-derived neurotrophic factor receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Insulin receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
ATP binding
insulin receptor activity
insulin receptor substrate binding
kinase activity
nucleotide binding
phosphorylation
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
transferase activity
transmembrane receptor protein tyrosine kinase activity

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InterPro
Fibronectin type III superfamily
Fibronectin type III
Furin-like cysteine-rich domain
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Receptor L-domain superfamily

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3480	FB:FBgn0283499
Drosophila melanogaster	3643	FB:FBgn0283499
Xenopus tropicalis	3645	Xenbase:XB-GENE-483108
Drosophila melanogaster	16001	FB:FBgn0283499
Drosophila melanogaster	16337	FB:FBgn0283499
Mus musculus	23920	Xenbase:XB-GENE-483108	MOUSE37602
Drosophila melanogaster	25718	FB:FBgn0283499
Drosophila melanogaster	42549	FB:FBgn0283499
Rattus norvegicus	60663	Xenbase:XB-GENE-483108	RATNO23812
Drosophila melanogaster	175410	FB:FBgn0283499

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LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements