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insulin receptor related receptor

Summary

Gene Symbol

INSRR

Organism

Homo sapiens (human)

External Links

NCBI Gene

3645

PubChem

3645

Alliance of Genome Resources

HGNC:6093

Annotation

Keyword

3D-structure
ATP-binding
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P14616	IR-related receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
male sex determination	IEA
actin cytoskeleton organization	IDA	21641549
cellular response to alkaline pH	IDA	21641549
protein autophosphorylation	IMP	21641549
insulin receptor signaling pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

insulin receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to alkaline pH

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

reproductive process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

multicellular organismal process [inference]

multicellular organism development

developmental process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

anatomical structure development [inference]

multicellular organism development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH [inference]

response to alkaline pH [inference]

cellular response to alkaline pH

cellular response to pH [inference]

cellular response to alkaline pH

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to alkaline pH

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to alkaline pH

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

insulin receptor signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
receptor complex	IDA	23382219
plasma membrane	IBA NAS	10226785
axon	IBA
insulin receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

insulin receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

insulin receptor complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

insulin receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

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GO Term	Evidence Code	PMID
protein binding	IPI	22939624 32296183 33961781 35384245
insulin receptor substrate binding	IBA
insulin receptor activity	IBA
phosphatidylinositol 3-kinase binding	IEA
transmembrane receptor protein tyrosine kinase activity	IDA NAS	10226785 21641549

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

insulin receptor a

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

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Gene Ontology
ATP binding
insulin receptor activity
insulin receptor substrate binding
kinase activity
nucleotide binding
phosphorylation
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
transferase activity
transmembrane receptor protein tyrosine kinase activity

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InterPro
Fibronectin type III superfamily
Fibronectin type III
Furin-like cysteine-rich domain
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Receptor L-domain superfamily

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:4194	glucose metabolism disease	Alliance of Genome Resources
DOID:535	sleep disorder	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9743	diabetic neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	23920		MGI:1346037	MOUSE37602
Drosophila melanogaster	42549		FB:FBgn0283499
Rattus norvegicus	60663		RGD:67399	RATNO23812
Caenorhabditis elegans	175410		WB:WBGene00000898
Xenopus laevis	398941		Xenbase:XB-GENE-864944
Pan troglodytes	457407	9598_0:00072e		PANTR22621
Canis lupus familiaris	490405			CANLF17380
Macaca mulatta	718670			MACMU23458
Bos taurus	787068			BOVIN25712
Monodelphis domestica	100023690			MONDO13528