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Insulin receptor-related protein

Summary

UniProt ID

P14616

Gene Symbol

INSRR
IRR

Gene ID

3645

Organism

Homo sapiens (human)

External Links

PubChem: P14616
The Human Metabolome Database: HMDBP01245
Re-Glyco: P14616

Annotation

Keyword

3D-structure
ATP-binding
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
plasma membrane
axon
receptor complex
insulin receptor complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 5** entries
GO Term
protein autophosphorylation
male sex determination
cellular response to alkaline pH
actin cytoskeleton organization
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying entries **1 - 10** of 22 in total

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GO Term
placental growth factor receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
hepatocyte growth factor receptor activity
insulin receptor activity
insulin-like growth factor receptor activity
platelet-derived growth factor beta-receptor activity
phosphatidylinositol 3-kinase binding
insulin receptor substrate binding
histone H2AXY142 kinase activity

Annotation information from UniProt.

Sequence

MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVCPGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	Source
47	N-linked (GlcNAc...) asparagine	UniProt
311	N-linked (GlcNAc...) asparagine	UniProt
411	N-linked (GlcNAc...) asparagine	UniProt
492	N-linked (GlcNAc...) asparagine	UniProt
528	N-linked (GlcNAc...) asparagine	UniProt
616	N-linked (GlcNAc...) asparagine	UniProt
634	N-linked (GlcNAc...) asparagine	UniProt
756	N-linked (GlcNAc...) asparagine	UniProt
885	N-linked (GlcNAc...) asparagine	UniProt
898	N-linked (GlcNAc...) asparagine	UniProt