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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
interferon regulatory factor 5
Summary
- Gene Symbol
-
- IRF5
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Antiviral defense
- Cytoplasm
- DNA-binding
- Inflammatory response
- Innate immunity
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Systemic lupus erythematosus
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13568 |
|
| A0A0G2USB5 |
|
| B7Z1M2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cellular response to virus | ||
| positive regulation of type I interferon production | ||
| response to peptidoglycan | ||
| response to muramyl dipeptide | ||
| regulation of transcription by RNA polymerase II |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| identical protein binding | ||
| sequence-specific double-stranded DNA binding | ||
| protein kinase binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Interferon regulatory factor 6
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| immune system process |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080547 | metabolic dysfunction-associated steatohepatitis | |
| DOID:0110895 | inflammatory bowel disease 14 | |
| DOID:13603 | obstructive jaundice | |
| DOID:1883 | hepatitis C | |
| DOID:2377 | multiple sclerosis | |
| DOID:5082 | liver cirrhosis | |
| DOID:5199 | ureteral obstruction | |
| DOID:552 | pneumonia | |
| DOID:7148 | rheumatoid arthritis | |
| DOID:8566 | herpes simplex |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 27056 | MGI:1350924 | MOUSE50125 | ||
| 296953 | RGD:1310447 | RATNO29878 | ||
| 405811 | ZFIN:ZDB-GENE-040426-2587 | DANRE32975 | ||
| 472512 | 9598_0:002063 | PANTR41376 | ||
| 482264 | CANLF03577 | |||
| 494760 | Xenbase:XB-GENE-998629 | |||
| 615340 | BOVIN28402 | |||
| 700725 | MACMU30888 | |||
| 734065 | Xenbase:XB-GENE-998624 | |||
| 100194823 | SALSA54262 |
