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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Dopamine transporter
Summary
- Gene Symbol
-
- DAT
- Organism
- Drosophila melanogaster (fruit fly)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Disulfide bond
- Glycoprotein
- Metal-binding
- Neurotransmitter transport
- Reference proteome
- Sodium
- Symport
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0B4KEX2 |
|
| Q7K4Y6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| norepinephrine transport | ||
| dopamine uptake involved in synaptic transmission | ||
| amino acid transport | ||
| sleep | ||
| sodium ion transmembrane transport |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| neuronal cell body membrane | ||
| plasma membrane | ||
| presynaptic membrane | ||
| axon |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| metal ion binding |
|
|
| cocaine binding | ||
| dopamine:sodium symporter activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Transporter
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| symporter activity |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:0050742 | nicotine dependence | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:0070489 | classic dopamine transporter deficiency syndrome | |
| DOID:0080832 | mild cognitive impairment | |
| DOID:0080855 | Parkinsonism | |
| DOID:0090145 | dopamine beta-hydroxylase deficiency | |
| DOID:10273 | heart conduction disease | |
| DOID:10763 | hypertension | |
| DOID:1094 | attention deficit hyperactivity disorder |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 108137965 | 30023_1:000ba0 | |||
| 108159069 | 7229_1:00249c | |||
| 108594811 | 30019_1:000a51 | |||
| 108616389 | 7263_1:0020a0 | |||
| 108654559 | 7232_0:000724 | |||
| 110188351 | 7274_0:0001f6 | |||
| 111079306 | 7282_0:00104b | |||
| 111596626 | 7224_1:002db3 | |||
| 115761056 | 47314_0:00127e | |||
| 117136394 | 7226_0:002adf |
