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STT3 oligosaccharyltransferase complex catalytic subunit A

Summary

Gene Symbol

STT3A

Aliases

MGC9042
STT3-A
TMC
dolichyl-diphosphooligosaccharide protein glycotransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3703

HGNC

6172

KEGG Gene ID

hsa:3703

PubChem

3703

Alliance of Genome Resources

HGNC:6172

Annotation

Keyword

3D-structure
Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Magnesium
Manganese
Metal-binding
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P46977	B5 Integral membrane protein 1 Transmembrane protein TMC

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IMP NAS	22467853 31831667
protein N-linked glycosylation via asparagine	IBA IMP ISS	19167329
post-translational protein modification	IBA
co-translational protein modification	IMP	19167329

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

Displaying **all 4** entries
GO Term	Evidence Code	PMID
oligosaccharyltransferase III complex	ISS
endoplasmic reticulum membrane	NAS TAS	31831667
oligosaccharyltransferase complex	IDA NAS TAS	19167329 22467853 31831667
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA IMP ISS	19167329 22467853
metal ion binding	IEA
protein binding	IPI	21903422 32707033 32814053 33845483 36217030

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

oligosaccharyl transferase activity [inference]

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K07151

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18]

References

12887896

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

Displaying entries **1 - 10** of 33 in total

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DO ID	Disease Name	Source
DOID:11832	visual epilepsy	DisGeNET
DOID:0050570	congenital disorder of glycosylation type I	DisGeNET
DOID:0080572	congenital disorder of glycosylation Iw	DisGeNET Alliance of Genome Resources
DOID:10112	sleeping sickness	DisGeNET
DOID:10113	trypanosomiasis	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:1094	attention deficit hyperactivity disorder	DisGeNET
DOID:13777	epidermodysplasia verruciformis	DisGeNET
DOID:1470	major depressive disorder	DisGeNET
DOID:1520	colon carcinoma	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 43 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000046	Small scrotum
HP:0000054	Micropenis
HP:0000219	Thin upper lip vermilion
HP:0000252	Microcephaly
HP:0000256	Macrocephaly
HP:0000276	Long face
HP:0000303	Mandibular prognathia

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:370921	STT3A-congenital disorder of glycosylation
OMIM:619714	congenital disorder of glycosylation, type Iw, autosomal dominant
OMIM:615596	STT3A-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003635
Gene Name: STT3A, subunit of the oligosaccharyltransferase complex (catalytic)

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33082	FB:FBgn0031149
Ciona intestinalis	100177361		CIOIN07652
Callorhinchus milii	103180290		CALMI20061
Latimeria chalumnae	102360886		LATCH16923
Danio rerio	266797	ZFIN:ZDB-GENE-021015-3	DANRE00608
Astyanax mexicanus	103035415		ASTMX02969
Ictalurus punctatus	108276860		ICTPU09452
Electrophorus electricus	113580714		ELEEL27035
Salmo trutta	115148899		SALTR20138
Salmo trutta	115154359		SALTR103556

GlyTouCan

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UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements