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STT3 oligosaccharyltransferase complex catalytic subunit A

Summary

Gene Symbol

STT3A

Aliases

MGC9042
STT3-A
TMC
dolichyl-diphosphooligosaccharide protein glycotransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3703

HGNC

6172

KEGG Gene ID

hsa:3703

PubChem

3703

Alliance of Genome Resources

HGNC:6172

Annotation

Keyword

3D-structure
Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Magnesium
Manganese
Metal-binding
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P46977	B5 Integral membrane protein 1 Transmembrane protein TMC

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
post-translational protein modification	IBA
co-translational protein modification	IMP	19167329
protein N-linked glycosylation via asparagine	IBA IMP ISS	19167329
protein N-linked glycosylation	IMP NAS	22467853 31831667

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

Displaying **all 4** entries
GO Term	Evidence Code	PMID
oligosaccharyltransferase complex	IDA ISS NAS TAS	19167329 22467853 31831667
membrane	HDA	19946888
endoplasmic reticulum membrane	NAS TAS	31831667
oligosaccharyltransferase III complex

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA IMP ISS	19167329 22467853
protein binding	IPI	21903422 30021884 32707033 32814053 33845483 35271311 36217030

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

oligosaccharyl transferase activity [inference]

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K07151

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18]

References

12887896

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080572	congenital disorder of glycosylation Iw	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **11 - 20** of 43 in total

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HPO ID	HPO Term
HP:0000431	Wide nasal bridge
HP:0000486	Strabismus
HP:0000718	Aggressive behavior
HP:0000750	Delayed speech and language development
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001270	Motor delay
HP:0001272	Cerebellar atrophy

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:370921	STT3A-congenital disorder of glycosylation
OMIM:615596	STT3A-congenital disorder of glycosylation
OMIM:619714	congenital disorder of glycosylation, type Iw, autosomal dominant

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003635
Gene Name: STT3A, subunit of the oligosaccharyltransferase complex (catalytic)

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UniCarb-DR

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Other Information

Tools

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Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements