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C-X-C motif chemokine receptor 4 S homeolog

Summary

Gene Symbol

cxcr4.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

380373

PubChem

380373

Alliance of Genome Resources

Xenbase:XB-GENE-6256540

Annotation

Keyword

Cell membrane
Cytoplasm
Disulfide bond
Endosome
G-protein coupled receptor
Gastrulation
Glycoprotein
Lysosome
Nucleus
Reference proteome
Sulfation
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A974BUH0
Q7ZXJ7	Stromal cell-derived factor 1 receptor B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
cellular response to cytokine stimulus	ISS
definitive hemopoiesis	ISS
chemokine-mediated signaling pathway	IEA
mesoderm migration involved in gastrulation	ISS
gastrulation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesodermal cell migration [inference]

mesoderm migration involved in gastrulation

cell migration involved in gastrulation [inference]

mesoderm migration involved in gastrulation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

multicellular organismal process [inference]

tissue migration [inference]

mesoderm migration involved in gastrulation

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

locomotion [inference]

taxis [inference]

chemotaxis

cell chemotaxis

response to stimulus [inference]

immune response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
endosome	IEA
lysosome	IEA ISS
nucleus	IEA
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chemokine receptor activity	IEA
C-X-C chemokine receptor activity	ISS
C-C chemokine receptor activity	IEA
G protein-coupled receptor activity	IEA
C-C chemokine binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
brain development
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
neurogenesis

Displaying **all 5** entries
InterPro
CXC chemokine receptor 4 N-terminal domain
CXC chemokine receptor 4/atypical chemokine receptor 2
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying entries **1 - 10** of 27 in total

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DO ID	Disease Name	Source
DOID:0050909	extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue	Alliance of Genome Resources
DOID:0060284	paroxysmal nocturnal hemoglobinuria	Alliance of Genome Resources
DOID:0060591	WHIM syndrome	Alliance of Genome Resources
DOID:0060901	lymphoplasmacytic lymphoma	Alliance of Genome Resources
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:11476	osteoporosis	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:2596	larynx cancer	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of **194** in total

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Species	Gene ID	OrthoDB
Alligator mississippiensis	102568735	8496_0:0047f0
Leptonychotes weddellii	102747594	9713_0:003189
Myotis davidii	102753258	225400_0:0038f8
Chrysochloris asiatica	102826819	185453_0:00095f
Elephantulus edwardii	102875703	28737_0:0031e7
Peromyscus maniculatus bairdii	102916770	230844_0:0036a2
Chelonia mydas	102947229	8469_0:0030e0
Physeter catodon	102989559	9755_0:00043d
Python bivittatus	103066628	176946_0:003738
Erinaceus europaeus	103115265	9365_0:00231e

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements