GlyCosmos Portal

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GO Term	Evidence Code	PMID
GTPase activity	EXP	18829532
GTPase activity	TAS	10436159
GTPase activity	IDA	19734146 19787194 26529257 27917469
GTPase activity	IBA
G protein activity	IDA	21565175

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

myosin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cell division control protein 42

Functional Category

T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 4** entries
Gene Ontology
GTP binding
nucleotide binding
protein kinase binding
small GTPase-mediated signal transduction

Displaying **all 4** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase Rho
Small GTPase

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3459	breast carcinoma	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 31 in total

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HPO ID	HPO Term
HP:0000272	Malar flattening
HP:0000324	Facial asymmetry
HP:0000431	Wide nasal bridge
HP:0000483	Astigmatism
HP:0000486	Strabismus
HP:0000501	Glaucoma
HP:0000518	Cataract
HP:0000545	Myopia
HP:0000568	Microphthalmia
HP:0000639	Nystagmus

Displaying 1 entry
Disease ID	Disease Name
OMIM:618727	ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies

PubChem Disease

MedGen Diseases

Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies

OMIM Phenotypes

ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES; EDFAOB

KEGG Diseases

Ectodermal dysplasia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 19 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	387	Xenbase:XB-GENE-941426
Saccharomyces cerevisiae S288C	388	SGD:S000006369
Xenopus tropicalis	389	Xenbase:XB-GENE-941426
Xenopus tropicalis	406411	Xenbase:XB-GENE-941426
Xenopus tropicalis	406659	Xenbase:XB-GENE-941426
Xenopus tropicalis	436718	Xenbase:XB-GENE-941426
Pan troglodytes	461014		PANTR31134
Xenopus tropicalis	856294	Xenbase:XB-GENE-941426
Xenopus tropicalis	100006041	Xenbase:XB-GENE-489222
Pongo abelii	100171605		PONAB25992

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements