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lactalbumin alpha

Summary

Gene Symbol

LALBA

Aliases

HAMLET
LYZG
LYZL7
lactose synthase B
lysozyme G

Organism

Homo sapiens (human)

External Links

NCBI Gene

3906

HGNC

6480

KEGG Gene ID

hsa:3906

PubChem

3906

Alliance of Genome Resources

HGNC:6480

Annotation

Keyword

3D-structure
Calcium
Direct protein sequencing
Disulfide bond
Glycoprotein
Lactose biosynthesis
Metal-binding
Milk protein
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P00709	Lactose synthase B protein Lysozyme-like protein 7
A0A080YV01	Lactose synthase B protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
apoptotic process	TAS	7644538
cell-cell signaling	TAS	7644538

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

lactose biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

lactose biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

lactose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

lactose biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of cellular process [inference]

signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi lumen	TAS
extracellular space	TAS	7644538
protein-containing complex	IEA
Golgi membrane	TAS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
lysozyme activity	IBA
lactose synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

lactose synthase activity

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

lactose synthase activity

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

lysozyme activity

peptidoglycan muralytic activity [inference]

lysozyme activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000167531

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00704

Name

alpha-lactalbumin [EC:2.4.1.22]

References

6285305

Disease

Disease Ontology

Displaying entries **1 - 10** of 18 in total

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DO ID	Disease Name	Source
DOID:11252	microcytic anemia	DisGeNET
DOID:11612	polycystic ovary syndrome	DisGeNET
DOID:11759	hypochromic anemia	DisGeNET
DOID:13121	deficiency anemia	DisGeNET
DOID:13922	eosinophilic esophagitis	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1754	mitral valve stenosis	DisGeNET
DOID:2326	gastroenteritis	Alliance of Genome Resources
DOID:2377	multiple sclerosis	DisGeNET

Ortholog

Displaying entries **41 - 47** of 47 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rhinopithecus bieti	108543906		RHIBE25187
Rhinopithecus roxellana	104654856		RHIRO22874
Nomascus leucogenys	100583850		NOMLE35923
Pteropus vampyrus	105297512		PTEVA00511
Propithecus coquereli	105805536		PROCO02782
Nannospalax galili	103750554		NANGA24095
Carlito syrichta	103273467		CARSF10185

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024