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laminin subunit gamma 1

Summary

Gene Symbol

LAMC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3915

PubChem

3915

Alliance of Genome Resources

HGNC:6492

Annotation

Keyword

3D-structure
Basement membrane
Cell adhesion
Coiled coil
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6NVY8
P11047	Laminin B2 chain Laminin-1 subunit gamma Laminin-10 subunit gamma Laminin-11 subunit gamma Laminin-2 subunit gamma Laminin-3 subunit gamma Laminin-4 subunit gamma Laminin-6 subunit gamma Laminin-7 subunit gamma Laminin-8 subunit gamma Laminin-9 subunit gamma S-laminin subunit gamma

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
positive regulation of muscle cell differentiation	NAS	26555376
protein-containing complex assembly	IDA	15159456
positive regulation of cell adhesion	NAS	3794389
maintenance of blood-brain barrier	NAS	30280653
positive regulation of epithelial cell proliferation	TAS	14557481

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

cellular component assembly [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

protein-containing complex assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

protein-containing complex organization [inference]

protein-containing complex assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

endoderm development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
laminin-10 complex	TAS	16236823
collagen-containing extracellular matrix	HDA ISS	20551380 22261194 23658023 25037231 27068509 27559042 28675934
laminin-1 complex	NAS TAS	10964500 14557481
endoplasmic reticulum lumen	TAS
basement membrane	IDA NAS	14557481 15159456 1678389 22952693

GO Hierarchy

cellular component

protein-containing complex [inference]

laminin complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular matrix structural constituent	IMP ISS RCA	15159456 20551380 25037231 27068509 27559042 28675934
extracellular matrix constituent conferring elasticity	RCA	25037231

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix constituent conferring elasticity

structural molecule activity conferring elasticity [inference]

extracellular matrix constituent conferring elasticity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

laminin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
animal organ morphogenesis
substrate adhesion-dependent cell spreading
tissue development

Displaying **all 4** entries
InterPro
EGF-like domain
Laminin IV
Laminin, N-terminal
Laminin-type EGF domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39118		FB:FBgn0267348
Rattus norvegicus	117036		RGD:621052	RATNO06737
Caenorhabditis elegans	180980		WB:WBGene00016913
Mus musculus	226519		MGI:99914	MOUSE27452
Danio rerio	286832		ZFIN:ZDB-GENE-021226-3	DANRE28628
Pan troglodytes	457570	9598_0:000891		PANTR23187
Canis lupus familiaris	480034			CANLF17171
Bos taurus	532572			BOVIN08756
Macaca mulatta	715265			MACMU21391
Monodelphis domestica	100023945			MONDO15818