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diacylglycerol O-acyltransferase 2

Summary

Gene Symbol

dgat2

Organism

Xenopus tropicalis (tropical clawed frog)

External Links

NCBI Gene

395003

PubChem

395003

Alliance of Genome Resources

Xenbase:XB-GENE-1017054

Annotation

Keyword

Acyltransferase
Cytoplasm
Endoplasmic reticulum
Glycerol metabolism
Lipid biosynthesis
Lipid droplet
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6P342	Acyl-CoA retinol O-fatty-acyltransferase Diglyceride acyltransferase 2
A0A8J1J1E6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
glycerol metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process

diacylglycerol biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
perinuclear region of cytoplasm	IEA
perinuclear endoplasmic reticulum membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

perinuclear region of cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	PMID
diacylglycerol O-acyltransferase activity	IBA IEA ISS
O-acyltransferase activity	IEA
acyltransferase activity	IEA
retinol O-fatty-acyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity [inference]

diacylglycerol O-acyltransferase activity

retinol O-fatty-acyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:10787	premature menopause	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 12 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179314	WB:WBGene00019464
Caenorhabditis elegans	189077	WB:WBGene00020910
Drosophila melanogaster	35718	FB:FBgn0033214
Drosophila melanogaster	35719	FB:FBgn0033215
Drosophila melanogaster	35720	FB:FBgn0033216
Danio rerio	565316	ZFIN:ZDB-GENE-050913-15
Xenopus laevis	398800	Xenbase:XB-GENE-6078761
Xenopus laevis	108710042	Xenbase:XB-GENE-17344138
Homo sapiens	84649	HGNC:16940
Mus musculus	67800	MGI:1915050

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024