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leptin
Summary
- Gene Symbol
-
- LEP
- Organism
- Homo sapiens (human)
Annotation
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| angiogenesis | ||
| ovulation from ovarian follicle | ||
| response to hypoxia | ||
| placenta development |
GO Hierarchy
- positive regulation of cold-induced thermogenesis
- positive regulation of cold-induced thermogenesis
- regulation of cell cycle
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of system process [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of biological quality [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| cytosol |
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA binding | ||
| hormone activity | ||
| hormone activity | ||
| hormone activity | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Leptin
- Functional Category
-
- G: Carbohydrate transport and metabolism
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Leptin |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:0111334 | congenital leptin deficiency | |
| DOID:10763 | hypertension | |
| DOID:11394 | adult respiratory distress syndrome | |
| DOID:11476 | osteoporosis | |
| DOID:14018 | alcoholic liver cirrhosis | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:4483 | rhinitis | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3952 | Xenbase:XB-GENE-980662 | ||
| 16846 | ZFIN:ZDB-GENE-041210-183 | MOUSE49858 | |
| 25608 | ZFIN:ZDB-GENE-081001-1 | RATNO29808 | |
| 280836 | BOVIN28376 | ||
| 396832 | PIGXX12627 | ||
| 449638 | PANTR41327 | ||
| 493838 | FELCA03850 | ||
| 698728 | MACMU33263 | ||
| 100008747 | RABIT11455 | ||
| 100014695 | MONDO33905 |
