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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
lysyl oxidase like 1
Summary
- Gene Symbol
-
- LOXL1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Cleavage on pair of basic residues
- Copper
- Disulfide bond
- Extracellular matrix
- Glaucoma
- LTQ
- Metal-binding
- Oxidoreductase
- Reference proteome
- Signal
- TPQ
- Proteins
| UniProt | Protein Name |
|---|---|
| Q08397 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| collagen fibril organization | ||
| aorta development | ||
| protein deamination | ||
| response to lipopolysaccharide |
| GO Term | Evidence Code | PMID |
|---|---|---|
| collagen-containing extracellular matrix | ||
| basement membrane | ||
| extracellular region | ||
| acrosomal vesicle | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein-lysine 6-oxidase activity | ||
| copper ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Lysyl oxidase
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| collagen fibril organization |
| copper ion binding |
| metal ion binding |
| oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
| oxidoreductase activity |
| InterPro |
|---|
| Lysyl oxidase, conserved site |
| Lysyl oxidase |
| SRCR domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1070 | primary open angle glaucoma | |
| DOID:10873 | Kuhnt-Junius degeneration | |
| DOID:13550 | angle-closure glaucoma | |
| DOID:13641 | exfoliation syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16949 | MGI:106096 | MOUSE62268 | ||
| 37485 | FB:FBgn0034660 | |||
| 281903 | BOVIN16680 | |||
| 315714 | RGD:1308752 | RATNO39719 | ||
| 453735 | 9598_0:003ef1 | PANTR10767 | ||
| 496210 | Xenbase:XB-GENE-1002054 | |||
| 560115 | ZFIN:ZDB-GENE-060503-693 | DANRE14381 | ||
| 706464 | MACMU40718 | |||
| 733215 | Xenbase:XB-GENE-17330433 | |||
| 100029444 | MONDO02170 |
