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kugelei

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

40191

PubChem

40191

Alliance of Genome Resources

FB:FBgn0261574

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
X2JCN4
Q9VW71	Protein kugelei

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
homophilic cell adhesion via plasma membrane adhesion molecules	ISS	10908592
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
growth of a germarium-derived egg chamber	IMP	19906848
open tracheal system development	IMP	15047711
salivary gland development	IMP	15047711

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

establishment or maintenance of cell polarity [inference]

establishment or maintenance of polarity of follicular epithelium [inference]

establishment of planar polarity of follicular epithelium

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of actin cytoskeleton polarity

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

follicle cell of egg chamber migration [inference]

centripetally migrating follicle cell migration

actin filament-based process [inference]

actin cytoskeleton organization [inference]

establishment or maintenance of actin cytoskeleton polarity

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

centripetally migrating follicle cell migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell leading edge

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

establishment or maintenance of actin cytoskeleton polarity

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of actin cytoskeleton polarity

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

growth of a germarium-derived egg chamber

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

follicle cell of egg chamber migration [inference]

centripetally migrating follicle cell migration

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

growth of a germarium-derived egg chamber

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity [inference]

establishment of planar polarity of follicular epithelium

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

oogenesis

animal organ development [inference]

gland development [inference]

salivary gland development

system development [inference]

respiratory system development [inference]

open tracheal system development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

growth [inference]

developmental growth [inference]

growth of a germarium-derived egg chamber

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell leading edge

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell leading edge

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of filopodium assembly

Displaying entries **1 - 5** of 7 in total

1

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GO Term	Evidence Code	PMID
plasma membrane	ISS	10908592
plasma membrane	IDA	19906848
plasma membrane	IEA
focal adhesion	IDA	19906848
basal plasma membrane	IDA	19906848

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basal plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell trailing edge

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium ion binding	ISM	11162110
calcium ion binding	IEA
protein-containing complex binding	IPI	26903538
cell adhesion molecule binding	IPI	26903538

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cell adhesion molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 3** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
focal adhesion	PMID:19906848
cell trailing edge	PMID:28292425
plasma membrane	PMID:19906848
actin-based cell projection	PMID:26903538
basal plasma membrane	PMID:19906848

Ortholog

Displaying **all 10** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	2195	Xenbase:XB-GENE-920279
Danio rerio	2196	ZFIN:ZDB-GENE-111031-1
Xenopus tropicalis	14107	Xenbase:XB-GENE-920279
Xenopus tropicalis	40191	Xenbase:XB-GENE-979369
Danio rerio	65048	ZFIN:ZDB-GENE-111031-1
Xenopus tropicalis	120114	Xenbase:XB-GENE-979369
Xenopus tropicalis	175590	Xenbase:XB-GENE-979369
Xenopus tropicalis	191571	Xenbase:XB-GENE-979369
Danio rerio	245827	ZFIN:ZDB-GENE-111031-1
Xenopus tropicalis	270120	Xenbase:XB-GENE-979369