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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
SMAD family member 6
Summary
- Gene Symbol
-
- SMAD6
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Craniosynostosis
- Disease variant
- Isopeptide bond
- Metal-binding
- Methylation
- Nucleus
- Phosphoprotein
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| O43541 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of ossification | ||
| negative regulation of osteoblast differentiation | ||
| anatomical structure morphogenesis | ||
| positive regulation of miRNA transcription | ||
| aortic valve morphogenesis |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi apparatus | ||
| protein-containing complex | ||
| heteromeric SMAD protein complex | ||
| nucleoplasm | ||
| chromatin |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| type I activin receptor binding | ||
| protein binding | ||
| co-SMAD binding | ||
| chromatin binding | ||
| transcription regulator inhibitor activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Mothers against decapentaplegic
- Functional Category
-
- K: Transcription
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| Dwarfin |
| MAD homology 1, Dwarfin-type |
| MAD homology, MH1 |
| SMAD MH1 domain superfamily |
| SMAD domain, Dwarfin-type |
| SMAD-like domain superfamily |
| SMAD/FHA domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0060912 | craniosynostosis 7 | |
| DOID:0080334 | aortic valve disease 2 | |
| DOID:10952 | nephritis | |
| DOID:6432 | pulmonary hypertension | |
| DOID:9827 | radioulnar synostosis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 17130 | MGI:1336883 | MOUSE63222 | ||
| 42059 | FB:FBgn0020493 | |||
| 116992 | ZFIN:ZDB-GENE-011015-1 | |||
| 172930 | WB:WBGene00006445 | |||
| 367100 | RGD:1305069 | RATNO42220 | ||
| 399369 | Xenbase:XB-GENE-481311 | |||
| 467711 | 9598_0:003dbd | PANTR10631 | ||
| 487612 | CANLF12629 | |||
| 511279 | BOVIN00505 | |||
| 564395 | ZFIN:ZDB-GENE-050419-198 | DANRE13700 |
